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A REVIEW ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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ABOUT AUTHORS:
1Rashmi Verma, 2Rakesh Tiwle
1Rungta College of Pharmaceutical Sciences & Research, Bhilai, 491024, C.G
2Shri Laxmanrao Maker Institute of Pharmacy, Amgaon, Gondia, Maharashtra, India- 441902.
rashmi.verma501@gmail.com

ABSTRACT
In the ancient age COPD has a variable natural history and not all individuals follow the same course about 15-20% of smokers develop clinically significant COPD. It is characterized by the airflow obstruction that is not fully reversible. It is predominantly caused by smoking, particularly occupational exposures, may also contribute to the development of COPD. Chronic obstructive pulmonary disease is diagnosed using a medical device called a spirometer, which measures air volume and flow, the main components of common clinical breathing tests (pulmonary function tests). Long-term exposure to lung irritants that damage the lungs and the airways usually is the cause of COPD. In this article we are focus about and detail review on the COPD.


NOVEL ANTI-DIABETES MECHANISM – NEXT GENERATION OF IMPROVED THERAPIES

ABOUT AUTHORS:
Kambham Venkateswarlu1*, N.Devanna2, R.Venu Priya3, P.Bharath Rathna Kumar4
1M.Pharm Scholar, Department Of Pharmaceutics,
2Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry,
3Faculty Of Pharmacy, Department Of Pharmaceutical Analysis,
4Director Of JNTUA-Otri
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur,
Anantapur District, Andhra Pradesh, India. Pin Code: 515001
k.v.reddy9441701016@gmail.com

ABSTRACT:
Scientists have uncovered a novel mechanism that dramatically increases insulin sensitivity and reduces the risk of developing type-2 DM and cardio vascular disease. According to American diabetes association, type-2 DM is closely associated to obesity. The new studies on DM focus on controlling a fat-regulating protein known as PPARg. In fact, excess body fat is the most problematic risk factor among all the factors of metabolic syndrome.  The formation of fat cells in the body is regulated by a protein called PPARg finding of drugs that can promote increased insulin sensitization but not activate the classical fat cell generating pathway of PPARg is the thrust area for research.  Hence targeting the fat regulating ability of this protein in order to treat DM important.


PRELIMINARY ASSESSMENT OF THE ANTIPROLIFERATIVE POTENTIAL OF THE HERBAL FORMULA "EKPO AGANWO"

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About Authors:
Enegide Chinedu*, David Arome, Solomon Fidelis Ameh
Department of Science Laboratory Technology (Physiology & Pharmacology Technology),
University of Jos, Jos Nigeria
chinex.snow@gmail.com

Abstract
Background:
Cancer is a major global public health problem and has metamorphosed to a leading cause of death globally. Latest predictions by the Word Health Organization suggest that cancer death rate may escalate to about 15 million deaths by 2030. Though various anticancer agents have been discovered and are in use currently, they have not been able to tame the disease effectively. This has left the scientific community with the task of discovering/developing better agents with high efficacy and minimal adverse effect. There have been increased interests by both developed countries and the scientific community towards the importance of herbs as a fountainhead in the development of newer drugs, as many classes of drugs now in use contain models from natual product. Ekpo aganwo (EA) is an herbal formulation prepared from the stem bark of Khaya senegalensis and is its main constituent.
Aim:
This study was design as a preliminary assessment of the antiproliferative potential of EA.
Materials and Method:
The modified Ayinde et al., bench top assay method was employed for the study.
Result:
Methotrexate compared with control, caused a significant (P<0.05) decrease in radicle lenght throughout the study. The percentage inhibition was however highest after 72 hours, with a rate of 86.67%. EA 10 mg/ml did not produce any significant decrease in radicle growth after 48 hours, but however showed a significant (P<0.05) decrease in radicle growth after 72 hours of experiment. The percentage inhibition after 72 hours was 24.56%. EA doses of 20 - 100 mg/ml produced significant (P<0.05) decrease in radicle growth throughout the experiment. The percentage inhbition of EA doses of 20 - 100 mg/ml was 28.07 - 59.65 % after 72 hours.
Conclusion: The results obtained have favoured the postulation of EA having an anticancer potential, and this have been supported by the significant antiproliferative activity it produced during the experiment.


DRUG INDUCED MITOCHONDRIAL TOXICITY: MECHANISTIC DIVERSITY AND DELETERIOUS CONSEQUENCES FOR THE LIVER

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About Authors:
Keyur S. Patel*, Mital Mehta
Department of Pharmacology,
Anand Pharmacy College, Anand.
Gujarat, India.
keyurpatel200189@gmail.com

Abstract
Drug-induced liver injury (DILI) has become a leading cause of severe liver disease and withdrawal of an approved drug from the market. DILI accounts for acute liver failure, liver transplantation or death in the United States today. A recent retrospective study indicates that the risk of DILI is enhanced when the administered daily dosage is higher than 50 mg or when the drug undergoes significant liver metabolism. Hence airs a major clinical and regulatory challenge.
This review Sum up Direct mitochondrial impairment and Specific drug induced mitochondrial dysfunction, current mechanistic concepts of DILI in a 2-step model that limits its principle mechanisms to this main ways of initial injury. Umpteen Studies that evaluate the risk of hepatotoxicity from Statins in Hyperlipidemic Patients.  In this article, It will review the pathogenesis of drug induced mitochondrial liver toxicity and deleterious consequences of Atorvastatin.


LIVER DISEASES: THERAPY WITH HERBAL MEDICINES

ABOUT AUTHORS:
Kambham Venkateswarlu1*, N.Devanna2, R.Venu Priya3, P.Bharath Rathna Kumar4
1M.Pharm Scholar, Department Of Pharmaceutics,
2Director Of JNTUA-Otri,
3Faculty Of Pharmacy, Department Of Pharmaceutics,
4Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry,
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur,
Anantapur District, Andhra Pradesh, India. Pin Code: 515001
k.v.reddy9441701016@gmail.com

ABSTRACT:
Therapies developed along the principles of Western medicine are often limited in efficacy, carry the risk of adverse effects, and are often too costly, especially for the developing world. Therefore, treating liver diseases with plant-derived compounds which are easily accessible and do not require laborious pharmaceutical synthesis seems highly attractive. When compared to allopathic medicines herbal medicines have some less side effects.


ROLE OF NMDA RECEPTORS IN BRAIN FUNCTIONS

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About Authors:
Emanual michael patelia*, Jigneshkumar Patel, Jayesh Patel, Rakesh Thakur, Zheying Zhu, Annamaria Gal, Emma Spiking, Bhavik Virani. Kaith.
University of Bedfordshire, England,
United Kingdom, LU1 3JU
ricky.emanual@gmail.com

Abstract:
There were the lots of expriements done on the NMDA (Ar-Mthyl-D-Aspartate) receptors. The general property of this kind of receptors is their complex and morphological structure. the larger structure like interconnections with the help of gap junctions and the expression of the potassium ion channels allows the K+ ions to transfer through channels and for this reason the homeostasis in the CNS is maintained. The cells like astrocytes are completely responsible for the maintainance of homeostasis in the CNS. Astrocytes contains AMPA and NMDA receptors are also responsible for Ca+2- dependent glutamate release. AMPA or NMDA receptors may produce the damage towards the oligodentrocytes with the help of Ca+2 dependent pathway. Moreover, the receptor studies regarding polydentrocytes having extensive proliferative behavior can able to convert into oligodentrocytes or astrocytes by changing their phenotype  With the help of immunochemistry, by contiet et al; showed the presence of the glial fibrilliary acidic protein and get the point that the rat who was deficient in  astrocytes have had the mRNA transcripts for GluN1 subunit.


LIVER CIRRHOSIS: A REVIEW

ABOUT AUTHORS:
Kambham Venkateswarlu1*, N.Devann2, R.Venu Priya3, P.Bharath Rathna Kumar4
1M.Pharm Scholar, Department Of PharmaCEUTICS,
2Director Of JNTUA-Otri,
3Faculty Of Pharmacy, Department Of Pharmaceutics,
4Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry,
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur, Anantapur District, Andhra Pradesh, India.
Pin Code: 515001

ABSTRACT:
Cirrhosis is defined as the histological development of regenerative nodules of liver parenchyma surrounded by fibrous septa in response to chronic liver injury. Chronic liver diseases represent a significant health problem across the globe with liver cirrhosis,an end stage consequence of fibrosis, being the major medical emergency with significant morbidity and mortality.
The exact prevalence of this life threatening disease worldwide is unknown as clinical spectrum of cirrhosis ranges from indolent, asymptomatic to complete hepatic decompensation. The progression of fibrosis to cirrhosis is lower in women than men due tothe protection offered by oestrogens. The ultimate curative option for liver cirrhosis currently is liver transplantation, which poses significant risk to the patient.


NUTRITION PLAN TO PROMOTE HEALTH & PREVENT DISEASES

About Authors:
1Govind shukla*, 1Sangita kumari, 2Anna victoria zamora maguddayao, 3Ms.Shivani prashar, 4C.J sampath kumar
1Research Scholar, JNTU, Hyderabad
2Head (RA&QA) Pharmasan Inc 525 A de Guzman St, Parang Marikina City PHILIPPINES
3Sr. Product Executive, Shrey Nutraceuticals Pvt. Ltd. New Delhi
4Managing Director, Lactonova India Hyderabad
govindbbd@gmail.com

Abstract
Nutrition(also called nourishment or aliment) is the provision, to cells and organisms, of the materials necessary (in the form of food) to support life. Many common health problems can be prevented or alleviated with a healthy nutrition.
Nutrition describes the processes by which all of the food a person eats are taken in and the nutrients that the body needs are absorbed. Good nutrition can help prevent disease and promote health.
Carbohydrate, Protein, Vitamins and minerals are an important part of nutrition. Vitamins are organic substances present in food. They are required by the body in small amounts to regulate metabolism and to maintain normal growth and functioning. Minerals are vital because they are the building blocks that make up the muscles, tissues, and bones. They also are important to many life-supporting systems, such as hormones, transport of oxygen, and enzyme systems.
A good nutrition plan will ensure that a balance of food groups, and the nutrients supplied by each group, is eaten A poor diet may have an injurious impact on health, causing nutrition deficiency diseases such as scurvy and kwashiorkor  health-threatening conditions like obesity and metabolic syndrome and such common chronic systemic diseases as cardiovascular disease, diabetes and osteoporosis. Present paper expresses the role of nutritional supplements on general health & disease conditions.


PHARMACOLOGICAL UPDATES OF PISTIA STRATIOTES (WATER LETTUCE/ JALAKUMBHI): A MINI REVIEW

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About Authors:
Kuntal Pal1, Sampat Kumar Kundu2
1Faculty of Ayurveda, Institute of Medical Sciences, Rajiv Gandhi South Campus,
Banaras Hindu University, Barkachha, Mirzapur-231001
2Gurunanak Institute of Pharmaceutical Science & Technology
Sodepur, West Bengal.
sampatkundu001@gmail.com

Abstract
World is running so first, at this moment medicines have to work to maintain the health of the people to give them power to stabilize them. Modern medicine is working from a decades or so, but many traditional systems of medicines also show some beneficial effects in that era. Likewise Kampo, Traditional Chinese Medicine(TCM), Ayurveda & Herbal Medicines. Those kind of medicines can give a patient resistant to protect the disease without less side effects. Pistia stratiotes is a plant which plays a commendable role in that era. It is used in different kind of disease which are described in this mini review.


TO STUDY THE EFFICACY AND EFFECTS ON LIPID METABOLISM, ANTHROPOMETRY AND BLOOD PRESSURE OF COMBINATION TREATMENT WITH ARB+HCTZ AND ACES+HCTZ IN HYPERTENSIVE PATIENT

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About Authors:
Rajak Sandeep1, Kothiyal Preeti2, Mathur Prashant1
1Department of clinical pharmacy,
2Department of pharmacology,
Division of Pharmaceutical sciences,
Shri Guru Ram Rai Institute of Technology And Sciences, Patel Nagar, Dehradun-248001, Uttarakhand, India
sandeep.rajak1886@gmail.com

Abstract
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are widely prescribed for the treatment of hypertension and heart failure, as well as for kidney disease prevention in patients with diabetes mellitus and the management of patients after myocardial infarction.Both combination therapies of an Angiotensin II receptor blocker (ARB) with the thiazide hydrochlorothiazide (HCTZ) and an Angiotensin converting enzymes (ACEs) with HCTZ are recommended to achieve blood pressure (BP) goals in antihypertensive treatment. However, although HCTZ is known to have unfavorable effects on lipid metabolism, the effects of HCTZ in the ARB+HCTZ and ACEs+HCTZ combination on lipid metabolism have not been fully elucidated. The objective of present study was “To study the Efficacy and Effects on Lipid Metabolism, anthropometry and blood pressure of Combination Treatment With ARB+HCTZ and ACEs+HCTZ in hypertensive patient.”

All prescription of hypertensive patients coming to the medicine OPD and IPD would be screened and those prescribed with  ACE-inhibitors+HCTZ and ARBs+HCTZ combination of  drugs will be selected for this study.


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