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  • Needle Free Injection Technology

    About Authors:
    Nimisha Paharia, Ankit Mittal, Garvita Joshi
    MAHAKAL INSTITUTE OF PHARMACEUTICAL STUDIES,
    UJJAIN (M.P.)

    ABSTRACT
    The pitfalls of needle-based injections are well known. A series of discoveries led to the development of the hypodermic needle which underwent significant changes. The first air-powered needle-free injection systems were developed during the 1940s and 1950s. Needle free delivery is done conveniently both for solids and liquids. Needle-free injection systems are typically made up of three components including an Injection device, disposable needle free syringe and air cartridge. Various needle free injectors are available in the market like Biojector, vitajet, iject, cool.click etc. These formulations are designed for better acceptability and patient convenience. They offer less pain and no needle phobia. They are ideally suited to chronic injections of varying doses of insulin, proteins and monoclonal antibodies.

  • Polymers in Mucoadhesive Drug Delivery System: A Brief Note

    About Authors: NIDHI KARIA1*, RAKHI CHANDAK1, ARATI  RATHI2
    1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
    2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

    Abstract:
    Bioadhesion can be defined as the process by which a natural or a synthetic polymer can adhere to a biological substrate. When the biological substrate is a mucosal layer then the phenomena is known as mucoadhesion. The substrate possessing bioadhesive property can help in devising a delivery system capable of delivering a bioactive agent for a prolonged period of time at a specific delivery site. The current review  provides  a good insight on mucoadhesive polymers, the phenomenon of mucoadhesion and the factors which have the ability to affect the mucoadhesive properties of a polymer.

  • Barrier Packaging as an Integral Part of Drug Delivery

    About Authors: NIDHI KARIA1, RAKHI CHANDAK1, ARATI  RATHI2
    1. P.WADHWANI COLLEGE OF PHARMACY,YAVATMAL
    2. ASST PROFFESER AT SUMANDEEP DEPARMENT OF PHARMACY, VADODARA

    INTRODUCTION:
    The advent of the new drug delivery systems (oral, nasal, pulmonary, transdermal, needle-free, etc.) and the development of new biochemical compounds have resulted in a need not only for enhanced protection against such factors as moisture, light, oxygen, or mechanical forces, but also for packaging forms to play a more integral role in drug delivery. A large number of lyophilized or freeze-dried drugs, for example, are currently available, and the list is growing. Biotech drugs by their very nature are much less stable than conventional compounds and demand a different mode of delivery. In this article, we will describe in more detail several examples of delivery systems to show how packaging, with an emphasis on blister and flexible materials, is being put to the test today.

  • RECENT TREDNS AND FUTURE PROSPECTS FOR SELF EMULSIFYING DRUG DELIVERY SYSTEM

    About Authors:
    Singh khushboo, Sharma monica,
    Ram gopal college of pharmacy,
    Gurgaon

    ABSTRACT
    Approximately 40% of new drug candidate have poor water solubility and oral delivery of such drug is frequently associated with implications of low bioavailabilty,high inter and intra subject variability, lack of dose proportionality. Bioavalibilty of lipophilic drug can be solved by formation of self emulsifying drug delivery system.SEDDS are belongs to lipid formulation and size range is from 100nm[SEDDS] less than 50nm[SMEDDS] and contain a isotropic mixture of oil, surfactant and co surfactant which are emulsified in aqueous media under condition of gentle agitation. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of emulsion in GIT with mild agitation provide by gastric motility, which present the drug in solubilized form,small size of formed droplet provided a large inter facial area for absorption,due to small globule size thAT can be easily absorb through lymphatic pathway, thereby passing hepatic pathway.

  • AN OVERVIEW OF APPROACHES IN DISSOLUTION TESTING: A REVIEW

    About Authors:
    Prashant L. Pingale, Anjali P. Pingale  
    Department of Pharmaceutics & Quality Assurance,
    School of Pharmacy and Technology Management, NMIMS Shirpur Campus
    Shirpur Dist: Dhule Maharashtra
    INDIA 425405.

    ABSTRACT:
    Tablets or capsules taken orally remain one of the most effective means of treatment available. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet or capsule is therefore crucial.
    Drug release in the human body can be measured ‘in-vivo’ by measuring the plasma or urine concentrations in the subject concerned. However, there are certain obvious impracticalities involved in employing such techniques on a routine basis. These difficulties have led to the introduction of official ‘in-vitro’ tests which are now rigorously and comprehensively defined in the respective Pharmacopoeia.
    Although initially developed for oral dosage forms, the role of the dissolution test has now been extended to ‘drug release’ studies on various other forms such as topical and transdermal systems and suppositories.

  • VALIDATION OF ANALYTICAL PROCEDURES: A COMPARISON OF ICH Vs PHARMACOPOEIA Vs FDA

    About Authors:
    Kataria Sahil,Middha Akanksha, Sandhu Premjeet
    Seth G. L. Bihani S.D. College of Technical Education,
    Institute of Pharmaceutical Sciences and Drug Research,
    Sri Ganganagar, Rajasthan, INDIA

    ABSTRACT
    Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability, and consistency of analytical results; it is an integral part of any good analytical practice. When extended to an analytical procedure, depending upon the application, it means that a method works reproducibly, when carried out by same or different persons, in same or different laboratories, using different  reagents,  different  equipment etc.  In  this  review  article  we  discussed  about  the  strategy  and  importance  of  validation  of  analytical  methods.

  • Review on Risk management techniques involved in curbing Arsenic Menace

    About Authors:
    Priya Pathak, Dr.H.H.Siddiqui*, Mr T.Mehmood
    Faculty of pharmacy
    Integral University,Lucknow

    ABSTRACT
    The article is a review on all the methods which have been evolved in recent times for curbing the menace caused by arsenic to our environment and humans. Arsenic poisoning is the most spread problem these days in India,as the main reasons of arsenic poisoning include the wastes being dumped by industries which in turn helps in increasing the amount of arsenic in groundwater. Mostly used method for removal of arsenic is oxidation of As(III) to As(V) and its subsequent removal through adsorption and/or precipitation.Generally alumina is used for adsorption purpose.Many methods have also been evolved for managing the increase of arsenic amount through wastes like Cement Solidification, Dolocrete Encapsulation Technology etc.which have been discussed later in the article. Many low cost technologies are also present like Arsenic removal plant fitted directly with hand pump, Co-precipitation-Sedimentation-Filtration under continuous flow system and use of Domestic filters.These techniques are used in case when large amount of water has to be treated as rest other technologies will become quite costly in this case.Although they cannot help in removing arsenic at large level but can be used in our daily life so that we could control arsenic pollution to some extent.

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  • VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN CALCIUM AND OLMESARTAN MEDOXOMIL IN TABLET DOSAGE FORM

    About Author:
    D. J. Kalena*, C. N. Patel
    Department of Quality Assurance,
    Shri Sarvajanik Pharmacy College,

    Near arvind baug, Mehsana - 384 001, Gujarat, India

    ABSTRACT
    Combination therapy of Atorvastatin calcium (AT) and Olmesartan medoxomil (OLM) is used for the treatment of coexisting essential hypertension and hyperlipidemia in adult persons. In the present study a simple, precise, rapid, efficient and reproducible reversed?phase high performance liquid chromatography (RP?HPLC) method has been developed for the simultaneous estimation of AT and OLM present in its tablet dosage forms. Chromatographic separations were carried out isocratically at 30°C ± 0.5°C on a Kromasil C18 Column (5 μm, 250mm x 4.60mm) with a mobile phase composed of Methanol: Acetonitrile: Water (pH 3.65) in the ratio of 50:27:23 % v/v at a flow rate of 1.0 ml/min. Detection is carried out using a UV detector at 260 nm. The retention times for AT and OLM were 5.3 ± 0.5 min and 3.4 ± 0.5 min respectively. The linearity range for AT and OLM were found to be 10?60 μg/ml and 20?120μg/ml with correlation coefficient of 0.996 and 0.999 respectively. The %recovery of the proposed method was found in the range of 98.36-100.91 for AT and 99.27-100.99 for OLM. The relative standard deviations for three replicate measurements in three concentrations of standard solution were always less than 2%. The results of the study showed that the proposed RP?HPLC method is simple, rapid, precise and accurate, which may be useful for the routine estimation of AT and OM in bulk drug and in its pharmaceutical dosage form.

  • METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF TORSEMIDE IN TABLET DOSAGE FORM

    About Authors:
    Kapil Sharma1*, Subhash Gupta 2, Yogesh Sharma1
    1 Yaresun Pharmaceuticals Pvt. Ltd.Jaipur - 302006, Rajasthan, India.
    2 Oasis test house ltd.jaipur-302006,
    Rajasthan, India.

    METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF TORSEMIDE IN TABLET DOSAGE FORM BY RP-HPLC AND UV SPECTROPHOTOMETRY AND COMPARISON OF TWO DEVELOPED METHODS BY USING t-TEST

    ABSTRACT
    One HPLC and one UV spectrophotometric method have been developed for the determination of torsemide (TRS) in tablet dosage form. The first method is based on determinetion of TRS in tablet dosage form by RP- HPLC method.  Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 288 nm and retention time of the drug was 7.05 min.  This method produced linear responses in the concentration range 60-140  µg/ml of torsemide. The accuracy of the method was assessed by recovery studies and was found to be 99.90± 0.41 for torsemide.  The second method is based on the estimation of torsemide in tablet dosage form by UV spectrophotometry using 50% v/v methanol in distilled water.  Beer’s law obeyed over the concentration range 2-26 µg/ml at 288 nm with apparent molar absorptivity of 1.26 x 104.  Both developed methods were found to be applicable for routine analysis of drug in tablet dosage form. The result of the analysis were validated statistically.The results were compared obtained from UV spectrophotometry and HPLC.

  • Microsphere: An Overview

    About Author:
    Rajesh Mujoriya
    Sardar patel college of technology,
    Balaghat, dis. Balaghat,
    MP–481001,INDIA

    Abstract
    Microspheres offer an excellent solution to creating precise pore sizes in ceramics at reasonable prices.  Polyethylene microspheres offer the added benefit of minimal residue after firing, and the availability in wide size ranges from a few micron up to 1000um (1mm).    Highly spherical microspheres have the added benefit of creating strong pores without any stress risers. Biodegradable microspheres are used to control drug release rates thereby decreasing toxic side effects, and eliminating the inconvenience of repeated injections. Microparticulate carrier system can be administered through different routes such as i.v,ocular,i.m,oral,intra arterial.etc.Each routes has it’s own biological significance, limitation & pharmaceutical feasibility.

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