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REVIEW ON HYDROGEL- A NOVEL CARRIER

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ABOUT AUTHORS:
C. Mallikarjuna*1, V. Hari Bhaskar1, Junju. Mohan Kumar2, Rayaprolu. Mounica2, Sai Padmini Bolla2
1Department of Pharmaceutics, Vagdevi College Of Pharmacy And Research Centre, SPSR Nellore, A. P, India.
2Department of Pharmaceutics, Rao’s College Of Pharmacy, SPSR Nellore, A. P, India.
Mallikarjuna2055@gmail.com

ABSTARCT
Hydrogels are three–dimensional cross-linked hydrophilic polymers that swell in water and aqueous solutions without dissolving in them. Softness, smartness, and the capacity to store water make hydrogels unique materials.Several techniques have been reported for the synthesis of hydrogels like co-polymerization/crosslinking of co-monomers using multifunctional co-monomer, which acts as crosslinking agent. They can be classified in different ways on the basis of their preparation, biodegradable properties, polymer, sensitivity to surrounding environment and also their application. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. This review mainly deals with the advantages, properties, method of preparation and characterization of hydrogels.


REGULATORY AFFAIRS: “STUDY REPORT OF NEW DRUG REGISTRATION PROCESS IN EUROPEAN UNION”

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About Authors:
Yogeshkumar B. Viradiya*, Manoj B. Dagwar, Swapnil T. Lanjewar
Institute of Management Sciences and Research (IMSR),
Nagpur, Maharashtra
viradiya2210@gmail.com

Abstract:
European Union is the big market for pharmaceuticals. Every pharmaceutical company wants to starts their business in European Union. In European Union come different countries like UK, Germany, France, Ireland, Sweden etc. In these countries various different process for new drug registration process like Nationalize process, Centralize process, Decentralize process, Mutual recognition process. Before that clinical trial approval also important for new drug registration. New drug registration process in European Union takes approximately 33 to 35 weeks. Each company must follow the rules and regulation for new drug registration. European medicine agency which gives the Clinical trial authorization and Marketing authorization to the new drug.


PREPARATION AND EVALUATION OF MATRIX TABLETS CONTAINING AMBROXOL HYDROCHLORIDE

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ABOUT AUTHORS:
Soma Vinisha*, Sajida Akhtari Begum, Nikhat Tabassum, Soma Anusha
Department of pharmaceutical science,
Bharat Institution of Techology, Hyderabad, India
choti.reddy@gmail.com

ABSTRACT
Purpose:
This study aimed to formulate Ambroxol hydrochloride SR matrix tablets using xanthan gum (natural polymer) and to elucidate the release kinetics of Ambroxol hydrochloride from xanthan gum-matrices. Methods: controlled release matrix tablets of ambroxol hydrochloride, a mucolytic expectorant  were prepared by wet granulation method using xanthan gum as natural hydrophilic polymer in three different ratios (Drug : Polymer 1:1(F-1), 1:1.5(F-2), 1:2(F-3)). The prepared granules of three different formulations were evaluated for angle of repose, bulk density (BD), tapped density (TD) and compressibility index (CI), hausners ratio. The prepared tablets were tested for physical parameters like weight variation, hardness, friability, content of active ingredient and In-vitro drug release studies. Results: The results obtained were within the prescribed limits. The release of ambroxol from the matrix tablets was sustained up to 12hrs. The cumulative percentage of drug release was decrease with increase in polymer concentration. Among the three formulations F-3 gave the release profile close to the commercially available marketed sample of ambroxol Hcl (A-MS).The results indicate that the drug release from the matrix tablets followed Zero order kinetics. The dissolution data was fitted to Korsmeyer equation which is used to describe the drug release behaviour from polymeric systems. All the formulations showed diffusion co-efficient value (n) greater than 0.43 but less than 0.85 after fitting to the Korsmeyer equation. So, it indicates Non-Fickian transport mechanism. Therefore the drug release is by diffusion and erosion mechanism. Conclusion: Matrix tablets of Ambroxol Hydrochloride using xanthan gum prepared by wet granulation method were found to be good in appearance. The drug-polymer ratio was found to influence the release of drug from the formulations. Formulation F-3 i.e. (1:2 drug: polymer) exhibited the similar In-vitro drug release rates as that of the marketed sample.


FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF AMBROXOL HYDROCHLORIDE

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ABOUT AUTHORS:
Samatha.M*, Deepthi.P, N. Srinivas
Department of pharmaceutics,
Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad
samathamapashetti@gmail.com

ABSTRACT
In the present study, an attempt was made to formulate the oral sustained release matrix tablets of AmbroxolHCl in order to improve the efficacy, reduce the frequency of administration, and better patient compliance. Ambroxol Hydrochloride is a potent mucolytic agent which induces bronchial secretions used in the treatment of respiratory disorders. FTIR analysis confirmed the absence ofany drug polymer interaction. Sustained release tablets of Ambroxol Hydrochloride were formulated employing hydrophilic polymers HPMC K4M and HPMC K100M. The powder blend was evaluated for micromeritic properties. The sustained release tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weightvariation test, hardness, friability, and drug content. The in vitro drug release characteristics were studied in simulated gastric fluid (2 hours) andintestinal fluid for a period of 10 hours using USP type II dissolution apparatus (total 12hours). The results of dissolution studies indicated that formulation F11 is the most successful of the study with satisfactory drug release. At the end of 12 hrs, the drug release was found to be 96.1%.


REGULATORY AFFAIR: LINK BETWEEN COMPANY AND GOVERNMENT AUTHORITY

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About Author:
Yogeshkumar B. Viradiya
Department of Regulatory Affairs, Institute of Management Sciences and Research (IMSR),
Nagpur, Maharashtra.  
viradiya2210@gmail.com

Abstract:
Regulatory affair is the very important department in Pharmaceutical Company. For the protection of public health, government of various countries have developed the regulation for pharmaceutical, cosmetic product, pesticides, veterinary medicines, medical device, agrochemical and complementary medicines by controlling the safety and efficacy of product. Regulatory affair department prepare the registration document which submits to the regulatory agency of various countries for approval of new drug which contain the all important information about new drug. It is called the drug master file of Common technical document (CTD). Regulatory affair is the link between company and government authority. Regulatory affair is important for Product management, Clinical trial, Research & Development. Regulatory personnel have to maintain contact with other specialist like chemist, doctors, veterinarians, engineers, pharmacologist, toxicologist, pharmacists, and accountant. Regulatory authorities of different countries prepare their separate rules and regulation. Main aim of regulatory affair department is to provide safe and effective medicine to people of different companies. Separate rules and regulation in different countries which must be followed by all pharmaceutical company in all over the world.


LIQUISOLID TECHNOLOGY: AN EMERGING AND ADVANCE TECHNIQUE FOR ENHANCING SOLUBILIZATION

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ABOUT AUTHORS:
Imran khan*, M. Idreesh khan, Unis khan
Dept. of Pharmaceutics in Shri Ram College of pharmacy, Banmore, Morena,
Madhya Pradesh, India
khan.imran731@gmail.com

ABSTRACT:
This is the novel approach for enhancing dissolution and bioavailability of BCS-II class drugs. Solubility is the major problem in the development of pharmaceutical dosage forms. Liquisolid technique is the novel and promising technique to overcome these problems. The liquisolid systems are to improve the dissolution properties of water insoluble agents. For enhancing the dissolution rates for water insoluble drugs we used carrier and coating materials like microcrystalline cellulose (Avicel), silica (Aerosil), sodium starch glycolate and magnesium stearate etc. These agents can significant effect on dissolution properties of water insoluble drugs.


FORMULATION AND EVALUATION OF CHEWABLE TABLETS OF MEBENDAZOLE BY DIFFERENT TECHNIQUES

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About Authors:
Fiza Farheen*, Sudhir Bharadwaj
Department of Phrmaceutics, Shri Ram College of Pharmacy,
Banmore, Morena (M.P.)
fizafarheen31@gmail.com

Abstract
The objective of the study was to develop an effective formulation of mebendazole chewable tablets. Mebendazole is a benzimidazole derivative with broad spectrum anthelemthic activity and excellent tolerability. Orally it is rapidly absorbed and metabolized tohydroxy  andhydroxyamino, which may be responsible for its anthelmenthic action. It is widely used in the treatment of worm infestations in both humans and animals. Mebendazole chewable tablets (200 mg) were prepared by three methods viz. non aqueous granulation, aqueous granulation and direct compression and were named as NAG, AG and DC respectively. Tablet prepared by these three methods were evaluated by different parameters such as average weight, hardness, carr’s index, tapped density, friability, disintegration, content uniformity test, in-vitro dissolution etc. All the parameters were found within the specifications. The study on the dissolution profile revealed that product ‘DChad faster dissolution rate while compared to remaining batches and marketed product. Assay values were within the limits of 90% to 110%.


A REVIEW ON OSMOTICALLY REGULATED SYSTEMS

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About Authors:
Fiza Farheen*, Sudhir Bharadwaj
Department of Pharmaceutics, Shri Ram College of Pharmacy banmore,
Morena (M.P.) india
fizafarheen31@gmail.com

Abstract
Osmotic devices are most promising strategy based systems for controlled drug delivery. These are among the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems or implant able devices. Osmotic pumps offer many advantages over other controlled drug delivery systems, i.e. they are easy to formulate and simple in operation, improve patient compliance with reduced dosing frequency and more consistent and prolonged therapeutic effect with uniform blood concentration. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semi permeable membrane. As the core absorbs water, it expands in volume, which pushes the drug solution out through the delivery ports. This article highlights the principle of osmosis, materials used for fabrication of pumps, types of pumps, advantages, disadvantages, and marketed products of this system.


HISTORY OF CATIONIC VS ANIONIC: IN NASAL DRUG DELIVERY SYSTEM

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ABOOUT AUTHORS:
Manu Sharma1, Shikha Chaudhary1, Dharmendra Kumar2*
1 R.V.Northland institute, greater Noida, Dadri, UP, India
2
Brahmanand Group of Institution, 195, Khurja G.T Road, Buldshahar Uttar Pradesh, India.
*rvnimiet@gmail.com

ABSTRACT
Chitosan as cationic and pectin as anionic are natural polysaccharides which show great potential in nasal drug delivery system. Chitosan’s are strongly poly-cationic. They are derivatives of poly-N-acetyl-D-glucosamine. Chitosan’s have positive charge that is responsible for mucoadhesion and play an important role in nasal drug delivery system Pectin’s have several structural elements: Homogalactouronan are smooth and Rhamnogalactouronan are hairy which play a very important role.By methyl esterifications, pectin’s are divided in two types: High methoxypectin’s and low methoxypectin’s. Low methoxypectin’s are very important in the formulation of nasal gel, because they have properties to form the gel with calcium ion (Ca2+).


SOLID DISPERSION: A TOOL TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

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ABOUT AUTHORS:
Ravindra M Hanwate*1, Dehghan M H G2, Saifee M2
1Department of Pharmaceutics, Dr.Vedprakash Patil College Of Pharmacy, Auranganad, Maharashtra, India
2Department of Pharmaceutics, Y.B.Chavan College of Pharmacy, Aurangabad, Maharashtra, India
* ravi_hanwate@yahoo.co.in

ABSTRACT
Solid dispersions have been used to increase the dissolution rates of poorly water soluble drugs. Many methods are used to prepare solid dispersions. This paper reports various solubility enhancement strategies in solid dispersion. The methods described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, spray drying technology, use of surfactant. The paper also shows study of characterization, selection of carriers, potential applications and limitations of these methods in solid dispersion.


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