Chemistry Articles

THALIDOMIDE AND ITS ANALOGUES IN ANTICANCER THERAPY

ABOUT AUTHORS:
Shikha Attri, Arti Choudhary, Devendra Gupta
M.Pharm in Pharmaceutical Chemistry, Lachoo
Memorial College of Science and Technology,
Jodhpur University, Rajasthan University Of Health Sciences, Jaipur
*shikhu921@gmail.com

ABSTRACT
Thalidomide, removed from clinical use because of severe teratogenicity, is back. In a comeback that has proceeded with remarkable speed, the drug that adversely affected more than 10,000 infants just over four decades ago now seems to be a lifesaver for patients with advanced plasma cell malignancies. Thalidomide and its immunomodulatory (IMiDs) analogs (lenalidomide, CC-4047, ACTIMID) are a novel class of compounds with numerous effects on the body’s immune system, some of which are thought to mediate the anticancer and anti- inflammatory results observed in humans. Thalidomide is currently being used experimentally to treat various cancers and inflammatory diseases. Immunomodulatory activities along with anti-angiogenic, anti-proliferative,and pro-apoptotic properties are thought to mediate the IMiDs’antitumor responses observed in relapsed and refractory multiple myeloma and some solid tumor cancers. This has led to their use in various oncology clinical trials.
A review is presented of the history of thalidomide and its analogues properties with an emphasis on applications in malignant disease.



NOVEL SYNTHETIC APPROACHES FOR THE TREATMENT OF MALIGNANT MELANOMA UNDER CLINICAL TRIAL

ABOUT AUTHORS:
Tara Shankar Basuri1*, Ishvar Parmar1, Vishal Modi2, Virag Shah3, Niyatee Thakur4
SSR College of pharmacy, Silvassa,
U.T of Dadra & Nagar Haveli-396230
*tbasuri@gmail.com

ABSTRACT
Malignant melanoma is the most lethal form of skin cancer and anincreasingly common disease worldwide. It remains one of the most treatment-refractorymalignancies. The current treatment options for patients with metastatic melanoma arelimited and in most cases non-curative. This review focuses on novel synthetic and herbal drugs for malignant melanoma treatment, by a single or combinational agent approach. These molecules are widely used by the oncologists for the treatment of this type of cancer. So this review can help to the public to aware the malignant melanoma and its treatment and novel target for its treatment.


IMPURITY PROFILING

ABOUT AUTHORS:
Sweety Sharma*, Amardeep Ankalgi, Chandra Shekhar Sharma, Hemendra Pratap Singh, Priyadarshani Kamble, Mahendra Singh Ranawat.
Deptt. Of Pharmaceutical Chemistry, B.N.College of Pharmacy,
Udaipur-313002, Rajasthan, India.
*sweet2pharma@gmail.com

ABSTRCT
Impurity is defined as any substance coexisting with the original drug, such as starting material or intermediates or that is formed, due to any side reactions. According to the International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) guideline on impurities in new drug substances, an impurity is defined as 'any component of the new drug substance that is not the chemical entity defined as the new drug substance’.Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, and HPTLC etc.  The most exploited techniques, for impurity profiling of drugs are LC-MS-MS, LC-NMR, LCNMR- MS, GC-MS, and LC-MS.


ASPECT OF NEUROSCIENCE AND NEUROCHEMISTRY

ABOUT AUTHORS
Chaitanya Prasad Meher*2 , M.V.Kumar1, V.Sravanthi1 , K.Ramya1, K.Satyanarayana1
1Maheshwara College  of Pharmacy, Chitkul, Isnapur,
Patancheru, Hyderabad-502307  (A.P)
2Assistant professor, Department of pharmaceutical chemistry,
Maheshwara College of Pharmacy, Hyderabad-502307  (Andhra Pradesh)

*chaitanyameher84@gmail.com

ABSTRACT
Neuroscience is a broad, multidisciplinary field concerned with the nervous system, its components, and functional activities, including behavior and consciousness. It relates to nerve cells function and development,  how do they communicate, how do brains work, and how have they evolved,  Nature of consciousness, and the neural basis for behaviors and for human brain dysfunction. These are among the many questions being answered by contemporary neuroscience. The present review article is concern on the aspect that usually reated to the neurochemistry.


SUNSCREEN & SUNSCREEN AGENTS : A REVIEW

About Authors:
*M.C.Sai HariKishan, C.P.Meher, S.M.Ahmed

Maheshwara Institute Of Pharmacy, Chitkul, Isnapur ,
Patancheru, Hyderabad-502307
*hari_mc@yahoo.com

ABSTRACT:
Sunscreen agents are used to prevent sunburn. Limiting the exposure to the sun and using sunscreen agents when in the sun may help prevent early wrinkling of the skin and skin cancer. There are two kinds of sunscreen agents: chemical and physical. Chemical sunscreen agents protect from the sun by absorbing the ultraviolet (UV) and visible sun rays, while physical sunscreen agents reflect, scatter, absorb, or block these rays.  Sunscreen agents often contain more than one ingredient. For example, products may contain one ingredient that provides protection against the ultraviolet A (UVA) sun rays and another ingredient that protects  from the ultraviolet B (UVB) sun rays, which are more likely to cause sunburn than the UVA sun rays. Ideally, coverage should include protection against both UVA and UVB sun rays.  The sun protection factor (SPF) that  find on the label of these products tells  the minimum amount of UVB sunlight that is needed with that product to produce redness on sunscreen-protected skin as compared with unprotected skin. Sunscreen products with high SPFs will provide more protection against the sun.The presented review article is concern with discussion on the sunscreen agents.


REVIEW ON ASYMMETERIC CATALYTIC HYDROGENATION

About Author:
Sarabjeet Kaur
M.pharm Lord Shiva College of pharmacy Sirsa
Teaching Assistant Dept of Pharm. Edu. and research, Bhainswal Kalan
BPSMV, Sonipat
jassarab@gmail.com

ABSTRACT:
Asymmetric hydrogenation is by far the most attractive form of stereoselective synthesis. Using optically pure catalysts, prochiral substrates can be converted to chiral compounds with high selectivity. These catalysts can be completely organic in nature (for example proline 50) or contain a transition metal which coordinates to an organic chiral ligand. In the last decades, considerable progress has been made in the development of metal catalyzed asymmetric transformation based on enantiopure ligands complexed to a transition metal core. However, the identification of suitable asymmetric catalysts still poses one of the most challenging endeavours in contemptory chemistry.


A REVIEW ON SUBSTITUTED BENZOTHIAZOLES

About Authors:
Swathi.Pathi*, Swarna Latha.D, M.Sreenivasulu.
Department of Pharmaceutical Chemistry,
Annamcharya college of pharmacy, newboyana pally, rajampet(M),
kadapa(dt). Andhara Pradesh, India.
*swathi.janu3@gmail.com

1. INTRODUCTION
A heterocyclic compound is one which possesses a cyclic structure with at least two different kinds of hetero atoms in the ring. Heterocyclic compounds are very widely distributed in nature and are essential to life in various ways1.
The chemistry and biological study of heterocyclic compounds has been an interesting field for a long time in medicinal chemistry. A number of heterocyclic derivatives containing nitrogen and sulphur atom serve as a unique and versatile scaffolds for experimental drug design2.
Benzothiazole is one of the most important heterocyclic compound, weak base, having varied biological activities and still of great scientific interest now a days. They are widely found in bioorganic and medicinal chemistry with application in drug discovery.


SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS

About Author:
ABHISHAK SINGH PARMAR,
M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
B.R.NAHATA COLLEGE OF PHARMACY,
MANDSAUR (M.P).
*abhishakparmar@gmail.com

1. INTRODUCTION
1.1 Medicinal and Pharmaceutical chemistry

It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1


SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL THIAZOLO[3,2-a]PYRIMIDINES

About Authors:
Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
Ahmedabad-382210, India.
*shaishavi21@rediffmail.com

Abstract
Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.


A MAJOR APPROACH- 2-CHLOROPYRIDINE-5-TRIFLUOROMETHYL DERIVATIVE AS ANTIAMNESIC AGENTS

About Author:
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
ravindratomar16@gmail.com

ABSTRACT-
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-


Pages

 

FIND MORE ARTICLES