You are hereChemistry Articles
M.pharm Lord Shiva College of pharmacy Sirsa
Teaching Assistant Dept of Pharm. Edu. and research, Bhainswal Kalan
Asymmetric hydrogenation is by far the most attractive form of stereoselective synthesis. Using optically pure catalysts, prochiral substrates can be converted to chiral compounds with high selectivity. These catalysts can be completely organic in nature (for example proline 50) or contain a transition metal which coordinates to an organic chiral ligand. In the last decades, considerable progress has been made in the development of metal catalyzed asymmetric transformation based on enantiopure ligands complexed to a transition metal core. However, the identification of suitable asymmetric catalysts still poses one of the most challenging endeavours in contemptory chemistry.
Swathi.Pathi*, Swarna Latha.D, M.Sreenivasulu.
Department of Pharmaceutical Chemistry,
Annamcharya college of pharmacy, newboyana pally, rajampet(M),
kadapa(dt). Andhara Pradesh, India.
A heterocyclic compound is one which possesses a cyclic structure with at least two different kinds of hetero atoms in the ring. Heterocyclic compounds are very widely distributed in nature and are essential to life in various ways1.
The chemistry and biological study of heterocyclic compounds has been an interesting field for a long time in medicinal chemistry. A number of heterocyclic derivatives containing nitrogen and sulphur atom serve as a unique and versatile scaffolds for experimental drug design2.
Benzothiazole is one of the most important heterocyclic compound, weak base, having varied biological activities and still of great scientific interest now a days. They are widely found in bioorganic and medicinal chemistry with application in drug discovery.
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS
ABHISHAK SINGH PARMAR,
M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
B.R.NAHATA COLLEGE OF PHARMACY,
1.1 Medicinal and Pharmaceutical chemistry
It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1
Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES
Aditya Dixit1, Gyanendra Kumar Sharma2, Devender Pathak*3
1M. Pharmacy (Pharmaceutical Chemistry)
2Associate Professor (Pharmaceutical chemistry)
3Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
Rajiv Academy for Pharmacy, Mathura,
Delhi-Mathura Highway, Chhattikara, 281006, India
A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, 1H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.
Zubair Khalid Labu1; AK Mohiuddin1; M.A Bake*2
1Department of Pharmacy, World University of Bangladesh (WUB), Dhaka-1215, Bangladesh
*2Product Development officer, Gonoshasthaya Pharmaceuticals Ltd., Mirzanagar, Savar, Dhaka-1344.
Food is the major source of energy in humans as well as animals. Foods are materials taken into the body by different route which provide nourishment in the form of energy or in the building of tissues. Food contaminants are substances that make food unfit for human consumption. Examples include bacteria, toxic chemicals, carcinogens, teratogens and radioactive materials. The purpose of these studies is to find out the food contaminants which are used in different purposes available in Bangladesh and contaminants detection method. After survey we found that Dhaka is the main city where food contamination by various contaminants in higher percentage. This contamination done by manmade, industrial discharge, poisonous water etc. Government of Bangladesh taking various necessary steps to stop this contamination.
Maheshwara Institute of Pharmacy,
Chitkul, Patancheru, Medak, A.P
Pyrazole, a 5-membered heterocyclic diazole alkaloid composed of three carbon atoms and two nitrogen atoms in adjacent positions, is a prevalent scaffold in drug discovery programs. The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety.This review highlighted recent reports of antimicrobial, anticancer, ACE inhibitory, antiviral as well as anti-inflammatory activities of pyrazole. The purpose of this review was to collate literature work reported by researchers on pyrazole for their varoius pharmacological activities and also reported recent efforts made on this moiety.
C.P.Meher*, D.V.Charan, S.P.Sethy
Maheshwara Institute of Pharmacy,
Chitkul, Patancheru, Medak, A.P
Heterocyclic chemistry is the branch of chemistry dealing with structure,synthesis, properties, and applications of heterocycles. heterocyclic compounds may be inorganic, most contain at least one carbon. Since in organic chemistry non-carbons usually are considered to replace carbon atoms, they are called heteroatoms, meaning 'different from carbon and hydrogen' (rings of heteroatoms of the same element are homocyclic). The IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds.The present review article is based on the condenced heterocyclic system quinoline derivatives with their tremendous pharmacological activities.
Lila dhar*, Prof. Sanjeev Thacker, Jatin Patel
Seth G. L. Bihani S.D. College Of Technical Education, Institute Of Pharmaceutical Sciences & Drug Research,
Gaganpath, Sri Ganganagar, Rajasthan 335001
Impurities is defined as an entity of drug substances or drug product that is not chemical entity defined as drug substances an excipients or other additives to drug product. In pharmaceutical world, an impurity is generally considered as an other organic material beside the other drug substances that is arises out of the synthesis most of the time, inorganic contaminants are not considered as an impurity unless they are toxic, such as heavy metal or arsenic. There are numerios source of impurities and many different common terms are use for impurities such as by product, intermediate, transformation on product, related product, interaction product and degradation products.