Factors Affecing Bio Availability

   Factors affecting absorption and Bio-availability

A) Physical properties

• Physical state
   
• Solubility of drug
   
• pH
   

B) Dosage form

• Particle size
   
• Disintegration and dissolution rate
   
• Formulation
   

C) physiological factors

 

• Gastric motility
• Ionization and gastric emptying
   
• Splanchnic blood flow
   
• Enterohepatic circulation
   
• Metabolism of drug
   
• Pharmacogenetic factors
   
• Disease state
   
• Route of administration
   
• Prensence of other substances