A Review: Determination of Itopride Hydrochloride in biological fluid and Pharmaceutical Dosage Forms

  • Posted on: 1 October 2014
  • By: admin

 

 

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PharmaTutor (October- 2014)

 

ISSN: 2347 - 7881
(Volume 2, Issue 10)

 

Received On: 12/08/2014; Accepted On: 19/08/2014; Published On: 01/10/2014

 

AUTHORS: Asif I Bhim*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat, India
bhimiqbal23@gmail.com

 

ABSTRACT:
Itopride Hydrochloride is a novel, synthesized, gastro prokinetic drug, which stimulates gastrointestinal motor activity through the synergistic effects of dopamine D2-receptor blockade and acetylcholine esterase inhibitors. Chemically, it is N-[[4-[2-(Dimethyl amino) ethoxy] phenyl] methyl]-3, 4-dimethoxy benzamide hydrochloride. Benzamide structure, amide and ether linkages in the drug molecule make it susceptible to degradation. Thus a prokinetic drug like Itopride Hydrochloride by virtue of its efficacy and tolerability could be considered as a drug of first choice and a welcome addition to the drug armamentarium for the symptomatic treatment of NUD (non-ulcer Dyspepsia) and other gastric motility disorders including functional bowel disorders. This review consists of various analytical methods for determination of Itopride Hydrochloride in various marketed pharmaceutical preparation and in biological fluids. Analytical method consists of various spectroscopic methods, chromatographic methods and other methods.

 

How to cite this article: AI Bhim, V Jain, R Hasumati; A Review: Determination of Itopride Hydrochloride in biological fluid and Pharmaceutical Dosage Forms; PharmaTutor; 2014; 2(10); 38-44

 

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