Zero Order and Area under Curve Spectrophotometric Methods for Determination of Fluoxetine Hydrochloride in Pharmaceutical Formulation

  • Posted on: 1 June 2015
  • By: admin

 

Magazine Home


JUNE 2015 ARTICLE LIST >>

PharmaTutor (June- 2015)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 6)

 

Received On: 12/03/2015; Accepted On: 16/03/2015; Published On: 01/06/2015

 

AUTHORS: Mali Audumbar*, Jadhav Santosh, Hake Gorakhnath, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
maliaudu442@gmail.com

 

ABSTRACT: Simple, fast and reliable spectrophotometric methods were developed for determination of Fluoxetine Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the zero order derivative values measured at 226 nm and the area under the curve method values measured at 220-231  nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Fluoxetine Hydrochloride using 5-25μg/ml (r²=0.999 and r²=0.997) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Fluoxetine Hydrochloride in tablets.

 

How to cite this article: A Mali, S Jadhav, G Hake, A Tamboli; Zero Order and Area under Curve Spectrophotometric Methods for Determination of Fluoxetine Hydrochloride in Pharmaceutical Formulation; PharmaTutor; 2015; 3(6); 49-54

 

[ABSTRACT WITH CITATION]   [VIEW AS HTML]