Development and Validation of Analytical Method for Simultaneous Estimation of Lamotrigine and Clozapine in Synthetic Mixture by Absorbance Correction Method

  • Posted on: 1 June 2015
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PharmaTutor (June- 2015)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 6)

 

Received On: 19/03/2015; Accepted On: 29/03/2015; Published On: 01/06/2015

 

AUTHORS: Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
*Shree Dhanvantary Pharmacy Collage, Kim,
Surat, Gujarat, India
*atodariya.priyanka@yahoo.com

 

ABSTRACT: The simple spectroscopic method has been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Absorbance Correction Method involves the measurement of absorption at two wavelengths 307 nm (lmax for Lamotrigine) and 360 nm (lmax for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method .The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1.The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.

 

How to cite this article: PP Atodariya, H Raj, VC Jain; Development and Validation of Analytical Method for Simultaneous Estimation of Lamotrigine and Clozapine in Synthetic Mixture by Absorbance Correction Method; PharmaTutor; 2015; 3(6); 41-48

 

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