JUN 2014 ARTICLE LIST >>
PharmaTutor (June- 2014)
ISSN: 2347 - 7881
Received On: 30/03/2014; Accepted On: 04/04/2014; Published On: 01/06/2014
AUTHORS: Imran khan*, M. Idreesh khan, Unis khan
Dept. of Pharmaceutics in Shri Ram College of pharmacy, Banmore, Morena,
Madhya Pradesh, India
*khan.imran731@gmail.com
ABSTRACT:
This is the novel approach for enhancing dissolution and bioavailability of BCS-II class drugs. Solubility is the major problem in the development of pharmaceutical dosage forms. Liquisolid technique is the novel and promising technique to overcome these problems. The liquisolid systems are to improve the dissolution properties of water insoluble agents. For enhancing the dissolution rates for water insoluble drugs we used carrier and coating materials like microcrystalline cellulose (Avicel), silica (Aerosil), sodium starch glycolate and magnesium stearate etc. These agents can significant effect on dissolution properties of water insoluble drugs.
How to cite this article: I Khan, MI Khan, U Khan; Liquisolid Technology: An Emerging and Advance Technique for Enhancing Solubilization; PharmaTutor; 2014; 2(6); 31-41
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Sathali Hasan Abdul A., and Deepa C., Formulation of Liquisolid tablets of Candesartan Cilexetil, Int. J. of Research in Pharmaceutical Sciences (IJRPS).2013; 4:(2), 238-249.
2. Rao Sambasiva A., Naga Aparna. T., Liquisolid Technology: An Overview, Int. J. of Research in Pharmaceutical and Biomedical Sciences (IJRPBS). 2011; 2:(2), 401-409.
3. Akinlade Babatunde, Elkordy A., Amal, Essa A., Ebtessam, Elhagar Sahar., Liquisolid Systems to improve the Dissolution of Furosemide, Scientia Pharmaceutica. 2010; 78, 325-344.
4. Chaudhary Amit, Nagaich Upendra, Gulati Neha, Sharma V. K., and Khosa R. L., Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review, J. of Advanced Pharmacy Education & Research (JAPER). 2012; 2:(1), 32-67.
5. Khalid M. El-Say, Ahmed M. Samy, Mohamed I. Fetouh., Formulation and evaluation of Rofecoxib liquisolid tablets, Int. J. of Pharmaceutical Sci. Research and Review (IJPSRR). 2010; 3:(1), 135-142.
6. Spireas S., Liquisolid systems and methods of preparing the same, Pharmaceutical Patent. 2002.
7. Javadzadeh Y., jafri B-navimipour and nokhodchi A., Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine), Int. J.Pharm. 2007; 341 :(1-2), 26-34.
8. Kulkarni Ajit S., Aloorkar Nagesh H., Mane Madhav S., and Gaja Jayashree B., Liquisolid systems: A Review, Int. J. of Pharmaceutical sciences and Nanotechnology (IJPSN). 2010; 3:(1), 795-802.
9. Kasture SV., Gondkar SB., Darekar AB., Dash P. and Bhambar KV., Enhancement of dissolution rate of Lansoprasole using liquisolid tablet technique, Int. J. of pharmaceutical research (IJPR). 2011; 3:(1), 27-31.
10. Rajesh K., Rajalakshmi R., Umamaheswari J., Kumar Ashok C.K., Liquisolid Technique a novel approach to enhance solubility and bioavailability, Int. J. of Biopharmaceutics (IJB). 2011; 2:(1), 8-13.
11. Yadav V.B., Yadav A.V., liquisolid granulation technique for tablet manufacturing: An overview, J. of pharmacy research (JPR). 2009; 2:(4), 670-674.
12. Tayel SA., Soliman I., and Louis D., Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique, Eur J Pharm Biopharm. 2008; 69, 342-347.
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