Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Olmesartan Medoxomil and Cilnidipine by Simultaneous Equation Method

  • Posted on: 1 June 2014
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PharmaTutor (June- 2014)
ISSN: 2347 - 7881

 

Received On: 04/04/2014; Accepted On: 09/04/2014; Published On: 01/06/2014

 

AUTHORS: Nehal C. Ghelani*, Krutika Bhalodiya, Ketan Dadhania, Shital Faldu
Department of Quality Assurance
Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
*nehalghelani10@gmail.com

 

ABSTRACT:
UV Spectrophotometric method has been developed for simultaneous estimation of Olmesartan Medoxomil (OLME) and Cilnidipine (CILNI) in bulk drug and in laboratory mixture. This method utilizes methanol as a solvent and λmax of Olmesartan Medoxomil and Cilnidipine selected for analysis was found to be 241 nm and 253 nm respectively. Linearity was observed in the Olmesartan Medoxomil concentration range of 4-20μg/ml and Cilnidipine concentration range 2 -10 ug/ml (r2 = 0.998 and r2 0.999) of both drugs. The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The proposed methods can be successfully applied for the routine analysis of both the drugs. This method was simple, rapid, accurate, and sensitive.

 

How to cite this article: NC Ghelani, K Bhalodiya, K Dadhania, S Faldu; Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Olmesartan Medoxomil and Cilnidipine by Simultaneous Equation Method; PharmaTutor; 2014; 2(6); 160-166

 

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