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Degradation Study of Ciprofloxacin Hydrochloride, Bromhexine hydrochloride and their Combined Pharmaceutical Dosage Form by Spectrophotometry

 

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PharmaTutor (July- 2014)
ISSN: 2347 - 7881

 

Received On: 26/04/2014; Accepted On: 04/05/2014; Published On: 01/07/2014

 

AUTHORS: Avinash M Nagapara1*, Hasmukh C Nagapara2, Darshan Madiya1, Shital Faldu1
1Department of Quality Assurance, Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
2Virani Science College, Rajkot, Gujarat, India
*avinashnagapara@yahoo.com

 

ABSTRACT:
A stress Degradation study of the combination containning Ciprofloxacin Hydrochloride and Bromhexine Hydrochloride was carried out by various reagent like 1 M NaOH, 1M HCl, 6% H2O2 and Neutral water at higher temperature. This combination is widely used for the treatment of various types of respiratory disorders and COPD. The effects of the various stress conditions were observed in terms of decrease in the peak hight, increase in peaks or slightly change or shifting of the wavelengths. It was found that by applying various stress conditions, 4% to 50% drugs were degraded in case of pure drugs as well as the Commercial formulation. Thus spectrophotometry was successfully utilised for primary stability study of the pure drug as well as the degradation study of Ciprofloxacin Hydrochloride and Bromhexine Hydrochloride.

How to cite this article: AM Nagapara, HC Nagapara, D Madiya, S Faldu; Degradation Study of Ciprofloxacin Hydrochloride, Bromhexine hydrochloride and their Combined Pharmaceutical Dosage Form by Spectrophotometry; PharmaTutor; 2014; 2(7); 102-109

 

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