Development and Validation of UV Spectrophotometric Estimation of Diclofenac Sodium Bulk and Tablet Dosage form using Area under Curve Method

  • Posted on: 1 April 2015
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PharmaTutor (April- 2015)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 4)

 

Received On: 22/01/2015; Accepted On: 30/01/2015; Published On: 01/04/2015

 

AUTHORS: Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola- 413307, Solapur, Maharashtra, India
maliaudu442@gmail.com

 

ABSTRACT
A simple, precise, accurate and economical UV visible spectrophotometric method has been developed for estimation of Diclofenac sodium drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05, 10, 15, 20 & 25 μg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.

 

How to cite this article: A Mali, S Jadhav, P Mane, A Tamboli; Development and Validation of UV Spectrophotometric Estimation of Diclofenac Sodium Bulk and Tablet Dosage form using Area under Curve Method; PharmaTutor; 2015; 3(4); 21-25

 

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