Shiv Nadar University is a comprehensive, multidisciplinary, research-focused and student-centric institution that is bringing a paradigm shift in higher education in India through its innovative curriculum, interdisciplinary focus, and cross-disciplinary thinking across a wide range of disciplines. The University is building an eco-system of knowledge to promote recognition of the inter-connectedness of ideas, systems, and environments in the world inside the campus, and those outside it. The University has 5 Schools, 18 Departments and 6 Research Centers engaged in teaching, practice, and research in disciplines as diverse as Engineering, Humanities & Social Sciences, Management, Natural Sciences, Art, Design, Performing Arts, Communication, and Extended Education & Professional Development.
Post : Project Assistant
Applicants should have expertise in :
1. Synthetic organic chemistry that includes synthesis, purification and characterization of small molecules and organic building blocks.
2. Prepare and conduct in-vitro assays
Desirable Skills :
• Small molecule synthesis experience with 2-3 years in the industry or research institution is preferred.
• Candidate should have good understanding of in vitro enzyme and phenotypic screening.
Funding Agency :
Funding agency is BIRAC. The Industrial PI of this project is Dr. Srinivas R Maddi from Acubiosys Pvt. Ltd., Technology Business Incubator, BITS-Pilani Campus, Jawahar Nagar, Hyderabad, Telanganat-500078, India. The Academic PI is Prof. Subhabrata Sen from Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH-91, Tehsil Dadri, Gautam Buddha Nagar, UP 201314, India.
About the Project :
The title of the project is “Preclinical pharmacokinetics and efficacy optimization of selective, potent Indoleamine-2, 3-dioxygenase inhibitors for the treatment of colorectal, breast and lung cancer”. Indoleamine-2, 3-dioxygenase (IDO) is a critical target for the treatment of cancer through immuno-oncology therapy. For a considerable amount of time, a substantial amount of research is ongoing to generate a clinical candidate for breast, colorectal and lung cancer which targets IDO. We have been able to develop efficacious molecules for this purpose.
The aim of this projects is three fold:
1. Generation of efficacious small molecules that inhibits proliferation of cancer cells by targeting IDO
2. Evaluation of physicochemical properties of new chemical entities (NCEs) developed so far.
3. Evaluation of In vitro ADMET properties of NCEs
4. Preclinical in vivo pharmacokinetics and efficacy in rodents
Minimum educational qualifications with age :
Project Assistant (PA): Possessing M.Sc./ M. Tech. (Chemistry/ Pharmaceutical Technology) or M. Pharm. with 55% marks. Age Maximum 35 years.
Age relaxation: Upper age limit is relaxable up to 5 years for SC/ST/OBC/Woman and Physically handicapped candidates as per CSIR rules.
The consolidated emoluments depending on qualification and experience will be :
Rs 25,000, as prescribed by the funding agency. In addition to stipend, the PA will be entitled to: HRA, as per rules of the Host Institution, provided he/she has not been given hostel accommodation.
Project Location : Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Tehsil Dadri, Gautam Buddha Nagar, UP 201314, India.
Tenure of the post : 1 year. The post will be co-terminus with the project
How to apply :
Please send your CV, a research statement, and have at least two letters of reference sent, by email to email@example.com with the subject “Application for SNU-BIRAC-Acubiosys-PA position” on or before 20th March 2020.
Short-listed candidates will be called for interview at the Shiv Nadar University campus (or through Skype). No TA/DA will be provided for appearing in this interview. Incomplete applications will be rejected without notice.
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