Pharmacy graduates apply now for Project Associate Post at NIBMG

BRIC-National Institute of Biomedical Genomics (NIBMG) Kalyani is an Institute of Government of India, Ministry of Science & Technology, Department of Biotechnology. The Institute has created the necessary physical infrastructure and critical platform technologies to support research, translation and trainingin biomedical genomics.

Post : Project Associate-I

Applications are invited for the position of Project Linked Person for extramural project to be executed by the BRIC-National institute of Biomedical Genomics, Kalyani. Selected applicants will be appointed initially for one year. The tenure of appointment may be extended depending on performance and availability of funds.

Project Name : Genetically Engineered Macrophage Microvesicles Carrying Human β- Defensin-2 for Targeted Treatment of Uropathogenic E. coli in Diabetic Bladder Infections

Principal Investigator’s name : Dr. Soumitra Mohanty

Research Description : Urinary tract infections (UTIs) are among the most common infectious diseases in India, and diabetes further increases susceptibility. While E. coli–uroepithelial interactions are well studied, the role of tissue-resident macrophages remains poorly understood. This project will investigate how macrophage-mediated regulation of antimicrobial peptides (AMPs) contribute to UTIs and assess whether boosting these host defences can offer a therapeutic alternative that reduces antibiotic resistance. We will examine how chronic glucose exposure affects microvesicle packaging and function, and whether restoring AMP expression can enhance their antimicrobial potential even under diabetic conditions. A major focus of this study is to define the molecular mechanism regulating AMPs in high glucose environments, particularly the role of long non-coding RNAs (lncRNAs). We will characterize lncRNA-mediated pathways, assess their presence in macrophage-derived microvesicles, and use CRISPR-based approaches to validate their regulatory functions. By elucidating how lncRNAs modulate AMP expression and microvesicle biology, we aim to uncover a host-directed therapeutic strategy to strengthen bladder defences. Overall, this research will advance understanding of diabetes- associated UTI susceptibility and may identify novel targets to prevent recurrent infections through modulation of macrophage-derived antimicrobial pathways.

Essential Education Qualification : 1) Four years Bachelor's Degree in Biological Sciences OR Master's Degree in Biological Sciences / BVSc /В. Pharm or Bachelor's degree in Engineering or Technology or Medicine from a recognized University or equivalent 2) Candidates have to be selected through a process described through any one of the following: (i) National Eligibility Tests - CSIR-UGC NET including lectureship (Assistant Professorship) or GATE. (ii) National level examinations conducted by Govt. of India Departments and their Agencies and Institutions such as DST, DBT, DAE, DOS, DRDO, MoE, ICAR, ICMR, IIT, IISc, ISER, NISER etc.

Desirable Qualification : Experience in mammalian cell culture, bacteriological techniques, knowledge in molecular biology techniques such as cloning, CRISPR mediated cell line generation, qPCR, western blot and other wet lab techniques. Candidates having prior experience of handling any pathogen such as S. aureus, P. aeruginosa or M. tuberculosis will be preferred

Nature of work & Responsibilities : Candidate is expected to do full time lab work involving data generation, analysis and proper documentation of data. Candidate is also expected to involve in other ongoing projects in lab and perform experiments as required by PI.

Consolidated and fixed monthly emolument (₹) : 37,000+30% HRA*
* If no suitable candidate is found then candidate may be given 30,000/- + 30% HRA for others who do not fall under 2 (i-ii) above.

This position is contractual, and appointments will be initially for one year, which is extendable depending upon performance and requirements of the project.
1. Interested candidates should submit their C.V. in prescribed format [Format is attached in the Page No. - 3] to hostpathogen.sm14lab@gmail.com with a subject line “Application for the post of PA-I in Project “Genetically Engineered Macrophage Microvesicles Carrying Human β-Defensin-2 for Targeted Treatment of Uropathogenic E. coli in Diabetic Bladder Infections” within 29-06-2026 midnight.
2. Interview Link (TEAMS) will be sent only to the shortlisted candidates.
3. Please visit our website nibmg.ac.in for further information.
4. If selected, you will be asked to produce all documents in original. If the documents don’t truly reflect what is mentioned in the advertisement, your application will be cancelled.
5. The decision of NIBMG in all matters relating to eligibility, acceptance or rejection of application, mode of selection, and conduct of interviews will be final and binding on the candidates.

Last Date : 29-06-2026
Place of Work : BRIC-NIBMG, Kalyani