NIBMG Pharma and Science Recruitment 2026 in Cancer Therapy Project

BRIC-National Institute of Biomedical Genomics (NIBMG) Kalyani is an Institute of Government of India, Ministry of Science & Technology, Department of Biotechnology. The Institute has created the necessary physical infrastructure and critical platform technologies to support research, translation and trainingin biomedical genomics.

Post : Project Associate-I

Applications are invited for the position of Project Linked Person (Project Associate-I, PA-I) for extramural project to be executed by the BRIC-National institute of Biomedical Genomics, Kalyani. Selected applicants will be appointed initially for one year. The tenure of appointment may be extended depending on performance and availability of funds

Project Name : Investigating the role of Arid1a in chromatin organization: Potential translation to cancer therapy

Principal Investigator’s name : Dr. Sriram Sridharan

Research Description : Genome instability is a “enabling hallmark of cancer” which can drive activation of the other hallmarks of cancer. Cellular maintenance includes a plethora of endogenous processes including DNA replication, transcription and chromatin organization. Several endogenous and exogenous disruptions frequently interfere with these cellular maintenance processes which need to be counteracted effectively to maintain the integrity of the genome. For this, mammalian systems have developed multiple pathways to counteract replication stress and DNA damage collectively known as the DNA damage response (DDR) pathways. However, the same pathways that normal cells utilize to maintain genome integrity in the face of these damages are also available to cancer cells to help overcome and survive elevated levels of DNA damage, replication stress and therapeutic intervention. Thus, understanding the genomic contexts that induce DNA damage and mechanisms utilized by cells to overcome this stress is very important in understanding cancer aetiology and designing effective therapeutic regimen. SWI/SNF chromatin remodelling factors are a family of ATP-dependent chromatin remodelling complexes that are critical for nucleosomal rearrangements thus allowing for regulation of gene expression. Arid1a is a subunit of this family of proteins, has been shown to have critical roles in regulation of DNA Damage Response (DDR), DNA replication and chromatin organization though complete characterization of these roles needs to be investigated in detail. It has important tumour-suppressor functions and found to be highly mutated across a spectrum of cancers. Loss of function mutations in Arid1a makes it challenging to treat these cancers leading to poor disease prognosis in patients. Studies proposed here focus on the interplay between chromatin organization, DNA damage and genome stability. More specifically, we aim to uncover the role of Arid1a in regulating higher-order genome organization. The overarching goal of this project is thus to understand the molecular mechanisms that underly genome organization and DNA damage response mediated by Arid1a using genetics, biological, single molecule, and genomics approaches. These questions proposed here will significantly broaden our understanding of the mechanisms contributing to genome integrity and how breakdown in these processes contribute to carcinogenesis and possible therapeutic resistance.

Essential Education Qualification : 1) Four years Bachelor's Degree in Biological Sciences OR Master's Degree in Biological Sciences / BVSc /В. Pharm OR Bachelor’s degree in engineering or technology or medicine from a recognized University or equivalent 2) Scholars have to be selected through i) National Eligibility Tests - CSIR-UGC NET including lectureship (Assistant Professorship) or GATE. (ii) National level examinations conducted by Govt. of India Departments and their Agencies and Institutions such as DST, DBT, DAE, DOS, DRDO, MoE, ICAR, ICMR, IIT, IISc, ISER, NISER etc.

Desirable Qualification : • Experience in mammalian cell culture and standard molecular biology techniques, including DNA/RNA extraction, PCR, qPCR, cloning, and protein analysis.
• Candidates having hands- on experience in CRISPR/Cas9-mediated genome editing, generation and validation of stable cell lines, and functional characterization of cellular phenotypes will be highly desirable.
• Prior experience in genomics techniques such as RNA-seq or related next- generation sequencing (NGS)-based assays will be highly desirable.
• Experience with sequencing library preparation and quality control of NGS samples will be an added advantage.

Nature of work & Responsibilities : The candidate will be expected to plan and execute experiments, analyze and interpret experimental data, maintain proper documentation of research findings, and actively participate in laboratory discussions and other research activities as assigned by the Principal Investigator. The candidate should demonstrate initiative in learning new methodologies, troubleshooting experiments, and keeping abreast of developments in the field.

Consolidated and fixed monthly emolument (₹) : 37,000+30% HRA *.

* If no suitable candidate is found then candidate may be given Rs. 30,000/- + 30% HRA for others who do not fall under 2 (i-ii) above [Essential Education Qualification]. This position is contractual, and appointments will be initially for one year, which is extendable depending upon performance and requirements of the project.

Interested candidates should submit their C.V. in prescribed format [Format is attached in the Page No. -3] along with a cover letter stating their background that fits with the project to ss16lab@gmail.com with a subject line “Application for the post of PA-1 in Project “Investigating the role of Arid1a in chromatin organization: Potential translation to cancer therapy” within 05-07-2026 [5PM].

1. Interview Link (TEAMS) will be sent only to the shortlisted candidates.
2. Please visit our website nibmg.ac.in for further information.
3. If selected, you will be asked to produce all documents in original. If the documents don’t truly reflect what is mentioned in the advertisement, your application will be cancelled.
4. The decision of NIBMG in all matters relating to eligibility, acceptance or rejection of application, mode of selection, and conduct of interviews will be final and binding on the candidates

Last Date : 05-07-2026 [5PM]
Place of Work : BRIC-NIBMG, Kalyani