The National Institute of Biomedical Genomics (NIBMG) is an Institute of Biotechnology Research and Innovation Council of Department of Biotechnology, Government of India. This is the first institution in India explicitly devoted to research, training, translation & service and capacity-building in Biomedical Genomics. It is located in Kalyani, West Bengal, India, near Kolkata.
Post : Project Research Scientist - I (non-medical) (1 post)
Project Title : Translational Decoding of TCR-Neoantigen Dynamics in Oral Precancerous Lesions Progression towards Frank Cancer : Integrating Spatial Sequencing and AI for Early Prediction Biomarker Development.
Oral Squamous Cell Carcinoma (OSCC) remains one of the leading causes of cancer-related mortality in India, largely driven by late-stage diagnosis and high recurrence rates. While oral precancerous lesions, such as Leukoplakia, are frequently identified during routine screenings, the lack of definitive molecular biomarkers makes it nearly impossible to predict which lesions will undergo malignant transformation. This project aims to bridge that gap by shifting the focus toward early intervention and immunogenomic risk stratification.
The project involves -
(i) combining high-throughput TCR sequencing with existing somatic mutation, gene expression, and methylation data from oral cancer patients.
(ii) utilizing cutting- edge spatial technologies to understand the regulatory roles and architectural nuances of the immune milieu in independent patient cohorts.
(III) developing a predictive AI/ML algorithm that integrates immunogenomic features for early disease progression risk assessment.
Essential Qualifications : Post Graduate Degree, including the integrated PG degrees in Biotechnology/ Biophysics/Bioc hemistry/ allied life-science related subjects.
Desirable Qualifications : (i) Experience in developing data analytical pipelines for NGS data analysis including genomics and transcriptomics (ii) Experience in variant calling from genomic data and generating count matrix from transcriptomic data and interpretation (iii) Good knowledge in Linux (iv) Documented experience in cell culture, NGS library preparation and functional assays
Nature of Duty : (i) Building pipelines for NGS data analysis (ii) Interpreting genomic and transcriptomic analytical results (iii) Report writing
Consolidated Remuneration [INR] per month : 56,000 + 30% HRA
Online Interview : This position is contractual, and appointments will be initially for one year, which is extendable depending upon performance, availability of funds and requirements of the project.
1. Interested candidates should submit their C.V. in prescribed format [Format is attached below] to applynkblab@gmail.com with a subject line “Application for the post of Project Research Scientist - I (Non-Medical) in the project Translational Decoding of TCR-Neoantigen Dynamics in Oral Precancerous Lesions Progression towards Frank Cancer: Integrating Spatial Sequencing and AI for Early Prediction Biomarker Development. Within 21-06-2026.
2. Please remember application/CV will not be accepted if not sent by prescribed format. 3. Interview Link (TEAMS) will only be sent to the shortlisted candidates.
4. If selected, you will be asked to produce all documents in original. If the documents don’t truly reflect what is mentioned in the advertisement, your candidature will be cancelled.
5. The decision of NIBMG in all matters relating to eligibility, acceptance or rejection of application, mode of selection, and conduct of interviews will be final and binding on the candidates.
NIBMG : Application Form & More Info
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