Nektar Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of drug candidates that utilize its PEGylation and polymer conjugate technology platforms, which are designed to improve the benefits of drugs for patients. Its product pipeline consists of drug candidates across a number of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology. Nektar's research and development activities involve small molecule drugs, peptides and other potential biologic drug candidates. Its drug candidates are designed to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability, metabolism or distribution of drugs and improve the overall benefits and use of a drug for the patient.
Post : Sr. Research Associate (India)
Job Description
Position Summary: Major role in development and optimization of analytical methods for raw materials and finished products, as per regulatory requirements. Formulation-analytical work would require knowledge and experience in handling liquid chromatography (HPLC, UPLC and preparative chromatography), gas chromatography (volatile organics, leachable and extractible studies), wet chemistry techniques (water analysis, pKa, partition coefficient), mass spectrometry (structural characterization by LCMS) etc. Performing Drug release experiments on Dissolution apparatus for solid dosage forms. Characterization of physico-chemical properties of molecules and excipients. Experience in interpretation of data from thermal analytical techniques (DSC, TGA, etc.), particle size characterization, X-ray crystallography (polymorphism and amorphous characterizations) etc. Preparation, review and maintenance of documents such as SOPs, protocols, reports and presentations. Analytical method transfer to other locations. Participation in meetings with stakeholders locally and globally, for project related updates, planning and strategies. Additional tasks as assigned by manager.
Responsibilities: Hands on experience in developing analytical methods for dosage forms like liquids, solids and injectable. Knowledge of drug discovery process and experience in testing of clinical trial batches (Phase I, II and III) supplies would be valuable. In depth knowledge of preformulation studies, material characterization (physical forms) techniques. Ability to work with limited quantities of API to develop robust methods. Excellent communication, presentation skills and scientific/technical writing skills. Demonstrate ability to manage time and resources effectively. Candidate must have a sense of urgency and desire to get things done effectively and efficiently. Must be able to demonstrate success in technical proficiency, scientific creativity, collaboration with others and independent thought process. Must be willing to work as a part of team and be able to demonstrate good interpersonal skills.
Candidate Profile
M.Sc /M.Pharm with specialization in Pharmaceutical Chemistry/ Chemistry/ Analytical Chemistry. 4-6 Years with M.Sc/ M.Pharm. Experience in Analytical R&D of drug product from a reputed pharmaceutical company. Experience with development, validation and technology transfer of analytical methods required to test drug products. Expert in method development using HPLC, UPLC, GC, Dissolution, wet chemical techniques, etc. Experience in analysis of Biologics (Peptides/Proteins, Enzymes, Monoclonal Antibodies) highly desired.
Additional Information:
Experience: 4-6 Years
Education: M.Sc /M.Pharm
Location: Hyderabad
Job ID: Job ID: IN3323-3455-R
Functional Area : Product Development
Industry Type: Pharma/ Biotech/Clinical Research
End Date: 28th July, 2018
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