Opening for M.Sc/ M.Pharm/ Ph.D as Senior Research Scientist in Piramal Life Sciences Limited

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Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.

Post: Senior Research Scientist

Job Description:
Key Roles/Responsibilities:

  • Perform Metabolomics studies to generate of metabolite profiling (endogenous metabolites) data from cell culture and biofluid samples using high resolution liquid chromatography-mass spectrometry (HR-LC-MS). Carry out complete activities in the Metabolomics pipeline, from sample preparation, MS-based metabolite analyses to data treatment and statistical analysis
  • Set-up MS based shotgun and comprehensive proteomics workflows to perform protein fractionation, 2D gel analysis, in-gel and in-solution sample preparation, label-free quantification, algorithm based database search and protein/peptide ID. Further, integration of proteomic data with metabolomic and pharmacological information to aid drug target discovery.
  • Maintain and operate MALDI, UPLC and nanoLC coupled with high resolution mass spec (HRMS) instrument such as Orbitrap and give training  to other team members
  • To utilize and further develop LC-MS/MS-based methods for both non-targeted and targeted metabolomics and drug metabolism ID (Met-ID) in biological matrices (in vitro matrices, cells, tissues, tumors, plasma and urine). Preparation of LC-MS method development reports, SOPs and protocol for qualitative and quantitative metabolite and protein analysis.
  • Tracer based metabolomics studies using HRMS tools such as isotopomer analysis, 13C labeled tracing of metabolism and flux analysis with survey, neutral-loss and precursor ion scans along with fragmentation tree generation, spectral interpretation and library search.
  • Structural identification and characterization of unknown metabolites using HRMS and MS/MS data
  • To coordinate with other research groups to plan and execute in vitro, cell culture, and animal based proteomic and metabolomic experiments
  • Generation and management of sample bank, metabolite and protein standards, spectral libraries and effectively integrate them with open-source databases
  • Perform large scale MS data processing and mining using software such as XCMS, Mzmine, MetAlign, R, Matlab, Mascot, Expressionist, SEQUEST and MetaboAnalyst.
  • Perform multivariate statistical data analysis using PCA, PLS, PLS-DA, OPLS methods and carry out network-based modeling of metabolomic and proteomic data sets

Additional Information:
Experience: 0-5 year for masters/ 0-3 years for Ph.D
Location: Goregaon, Mumbai
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area: R&D

Applications may be sent to :

The subject line may read 'Application for RS/Analytical Discovery/001*.’

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