Require Senior Research Scientist - Drug Metabolism & Pharmacokinetics in Piramal Life Sciences Limited
Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.
Post: Drug Metabolism & Pharmacokinetics - Senior Research Scientist
Set-up and perform mass spectrometry-based comprehensive proteomic workflows including protein fractionation, 2D gel analysis, in-gel and in-solution sample preparation, protein ID, peptide mass fingerprinting, label-free quantification and data analysis. Further, integration of proteomic data with metabolomic and pharmacological information to support drug discovery and development
Maintain and operate nanoLC-HRMS (high resolution mass spec), MALDI-TOF and UPLC-MS/MS instruments such as Q-Exactive Orbitrap and Q-TOF LC/MS. Also train and assist other team members
Perform large scale MS data processing and mining using various software such as Proteome Discoverer, MassFrontier, MetAlign, R, Matlab, Mascot, Expressionist, SEQUEST etc
Generation and maintenance of biological sample bank, metabolite and protein standards, spectral libraries and databases
Independently execute high-throughput proteomic and metabolomic sample preparations for in-vitro and in-vivo biological samples
Hands-on experience in operating and maintaining high resolution mass spec instruments
Experience in application of proteomic technology for target discovery and studying cancer metabolism is highly desirable
Should have strong communication, interpersonal and data presentation skills to coordinate with other drug discovery and development groups
Having industrial experience in small molecule Metabolomics, pharmacokinetics, drug metabolism (Metabolite -ID) and in vitro assays using LC-MS will have an added advantage
Experience: 0-5 years for Masters/ 0-3 years for Ph.D
Location: Goregaon, Mumbai
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area: R&D
Education: M.Sc, M.Pharm, Ph.D
End Date: 26th March, 2014
In case you wish to apply to this position, please send us your CV
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The subject line may read ' DMPK Proteomics - 001 '
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