A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.
Post : Investigator - PK Sciences
Job Description
As part of an integrated team, the successful candidate will be responsible for method development of LC-MS/MS quantitative assay and sample analysis for small molecule and large molecule drug candidates in biological samples supporting nonclinical and discovery PK, in preclinical species. The candidate will also help lead development of new technologies and assays for the screening and quantification of discovery PK biologics. This includes the preparation of method and bioanalytical data reports, and calculation of pharmacokinetic parameters. The position requires an individual to be capable of using multiple instrument software programs and a laboratory information management system (LIMS) for the calibration and quantitation of raw data, and standard word processing and spreadsheet applications. The position involves working with CRO’s for the outsourcing of PK studies. The candidate will also spend a portion of their time on new initiatives such as development of LC-MS and MS/MS assays for biologics. The candidate should understand key principles underlying relevant technologies and protocols in own discipline and closely related areas. The candidate will also have a strong knowledge of ligand binding and biological assays.
Key Activities
• Responsible for conducting all bioanalytical work with respect to scientific integrity, quality, and timelines.
• Establishing new LC-MS based assays for the quantification of biologics from biological matrices.
• Establishment, troubleshooting and performing of advanced method development, and sample analysis in discovery and pre-clinical studies.
• Work with key stakeholders to execute Bioanalytical preclinical strategy and ensure performance metrics are maintained.
• Collaborate effectively and efficiently with internal customers and external providers in order to establish good working relationships while ensuring high quality deliverable
Candidate Profile
The candidate should have an M.S. with a minimum of 5-8 years of hands-on experience in HPLC and LC-MS/MS or a Ph.D. degree in Chemistry or Biochemistry or related field. The candidate should be capable of working independently under moderate supervision and should possess good writing and verbal communication skills. An excellent working knowledge of general laboratory techniques, HPLC and LC-MS/MS operation, and troubleshooting and method development is essential. A strong background in analytical problem solving is also required. Proficiency with personal computer applications for word processing, spreadsheets and graphics are desirable.
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Other Minimum Requirements
• Excellent presentation skills.
• Familiarity with digital system and the ability to write basic scripts or macros is desirable.
• Good attention to detail, an analytical investigative and questioning nature, with an innovative solution-oriented approach.
• Well developed interpersonal skills with good presence; experienced presenter and communicator.
• A self-starting and decisive individual; open, confident and persuasive, succeeding through influence.
• Good planning, prioritization, problem solving, organizational and multi-tasking skills.
• Resilient, energetic and enthusiastic; responding constructively to challenging new ideas and inputs.
• Team player, ability to be flexible and adapt to a changing environment.
Additional Information:
Experience: 5-8 years
Location: USA
Education: M.Sc, Ph.D
Industry Type: Pharma/ Biotech/Clinical Research
Functional Area: Research & Development
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