Post-doctoral fellowship is offered at the University of Cape Town’s Holistic Drug Discovery and Development Centre (H3D), housed in the Department of Chemistry. This is a drug repurposing project and will integrate AI/ML-based drug screening (approved or marketed) with experimental validation and translational pharmacokinetic- pharmacodynamic (PK-PD) modelling to identify, evaluate and prioritize medicines with antiviral activity against viruses belonging to the Flaviviridae (yellow fever virus, Zika virus, dengue virus, and hepatitis C virus), Coronaviridae (SARS- CoV-2) and Filoviridae (Ebola virus) families. With guidance, you will learn and apply translational PK-PD modelling and AI/ML-based drug screening to identify the hits for potential antiviral drugs.
POSTDOCTORAL FELLOWSHIP
Why join us?
• Work at H3D, Africa’s first integrated drug discovery and development centre with state-of-the-art facilities
• Benefit from the experience at H3D, where the first clinical candidate (the antimalarial MMV048) on the African continent was developed
• Profit from internal and external mentorship programs across the different disciplines: medicinal chemistry, DMPK, enzymology, disease-focused biology, computer-aided drug discovery (CADD) and artificial intelligence & machine learning (AI/ML)
• Become part of H3D’s projects, including international collaborations and gain access to a worldwide network of leading scientists from industry and academia
Call for Applications : Applicants who meet the following criteria are invited to apply for this fellowship.
• South African, Permanent Resident, citizen from SADC countries/foreign
• The successful applicants must have achieved a PhD degree in pharmaceutical science, biochemistry, biology
or any relevant health sciences within the past 3 years
• Candidate must have adequate experience in computational/analytical skills as evidenced by the track record
of publications in reputed international journals.
• The successful applicants must be prepared to comply with the University's approved policies, procedures, and
practices for the postdoctoral sector.
Conditions of Award (General) : The following are the general conditions of the award:
• Postdoctoral research fellowship is only available to individuals who have achieved a doctoral degree within the
past 3 years.
• Applicants must not previously have held full-time permanent professional or academic posts.
• Applicants are required to be in Cape Town at UCT for the duration of the research.
• No benefits or allowances are included in the value of the fellowship
The value of the Fellowship : R350 000 – R400 000 tax-free (depending on seniority and experience).
Period : One year, renewable as per UCT policy, contingent on satisfactory progress and the availability of funds.
Application Process :
• To apply, please e-mail the documents below addressed to Professor Kelly Chibale, Director of H3D,
Department of Chemistry, in a single pdf file to Ms Chanté Foentjies (chante.foentjies@uct.ac.za).
* A 1-page cover letter of application (stating areas of expertise, research interests, and experience)
* A CV containing a brief summary of research work and a list of publications
* Names and contact details of references who have taught, supervised, or worked alongside the applicant,
* Copies of academic transcripts
The H3D Postdoctoral Recruitment sub-committee and H3D EXCO will consider eligible and complete applications. The successful applicant must ideally be available to commence with the Fellowship as soon as possible. The closing date for applications is 7th September 2026. Shortlisting will take place shortly thereafter. If applicants do not hear back from the sub-committee, kindly assume your application was unsuccessful.
To apply, please e-mail the documents below addressed to Professor Kelly Chibale, Director of H3D,
Department of Chemistry, in a single pdf file to Ms Chanté Foentjies (chante.foentjies@uct.ac.za).
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