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  • AICTE Sponsored National Seminar on Current and Recent Advancement in Targeted Drug Delivery System (Sunday & Monday) February 9th & 10th, 2014 at Kota College of Pharmacy

    Kota College of Pharmacy Kota, affiliated to Rajasthan University of Health Sciences. Jaipur is approved by All India Council of Technical Education, New Delhi, Pharmacy Council of India, New Delhi and Government of Rajasthan. Established in 2004, the college offers undergraduate course in Pharmaceutical Sciences and Post Graduate courses in Pharmaceutics and Pharmacology. KCP has strong research foundation with AICTE funded Research Projects, Entrepreneur Development Cell (EDC1 and DST Projects by Govt, of Rajasthan. Five batches of BPharm. and one batch of M.Pharm. have already passed from the college. The college provide most effective teaching learning environment using latest teaching aid and equipments. The college is approved centre for guiding research in the area of Pharmaceutical Science.

  • BABY TOILETRIES : A SHORT EXPLANATION

    The constantly increasing sales volume of baby toiletries in the overall cosmetic market indicates their relative importance to the consumer, manufacturer, retailer and pediatrician. These products include:

  • PHARMACEUTICAL GELS: IN SUMMARIZED FORM

    About Author:
    Piyush Tripathi
    Kota College of Pharmacy,
    Kota (RAJ)
    piyushtripathi1992@rediffmail.com

     

    Definition:
    A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid4.

  • CLINICAL RESEARCH: TRIALS & SCOPE

    About Author:
    Mr. Piyush Tripathi
    Kota College of Pharmacy
    Kota, Rajasthan.
    piyushtripathi1992@rediffmail.com

    Introduction:
    The term Clinical Research refers to the entire bibliography of a drug from its inception in the lab to its introduction to the consumer market & beyond. Not every compound that is tested in the lab is marketed. Before a drug is marketed, it has to undergo several stages of development.

  • ROLE OF CAVEOLAE IN HEALTH & DISEASE

    About Author:
    Mr. Piyush Tripathi
    Kota College of Pharmacy,
    Kota (RAJ).
    piyushtripathi1992@rediffmail.com

    Introduction:
    In biology, caveolae (Latin for little caves, singular: caveola), which are a special type of lipid raft, are small (50–100 nanometer) invaginations of the plasma membrane in many vertebrate cell types, especially in endothelial cells and adipocytes.

    These flask-shaped structures are rich in proteins as well as lipids such as cholesteroland sphingolipids and have several functions in signal transduction. They are also believed to play a role in endocytosis, oncogenesis, and the uptake of pathogenicbacteriaand certain viruses.

  • DRUG DEVELOPMENT, ESPECIALLY “CANCER” BASED ON MOLECULAR BIOMARKERS

    ABOUT AUTHORS:
    Piyush Tripathi*, Rahul Sharma, Shanti Bhushan Mishra
    Kota College of Pharmacy, Ranpur,
    Kota-325003 (Rajasthan) India.
    *piyushtripathi1992@rediffmail.com

    ABSTRACT
    A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. A biomarker is a parameter that can be used to measure the progress of disease or the effects of treatment. In the treatment of diseases especially “Cancer”, there is a shift from the traditional clinical practices (drugs with low toxicity) to novel approaches. Currently, effective treatment is available for only a small percentage of cancer patients.These novel approaches are intended to identify individualized patient benefits of therapies, minimize the risk of toxicity and reduce the cost of treatment. The biggest challenge for researchers and clinicians today is, to decide on which type of biomarker to use across the wide spectrum of disease processes. In cancer, genomic studies are valuable because every cancer cell shows some degree of genetic damage. Biomarkers have the ability to greatly enhance cancer detection and the drug development process. In addition, biomarkers will enable physicians to develop individualized treatment plans for their cancer patients; thus allowing doctors to tailor drugs specific to their patient's tumor type.

  • SUPERDISINTEGRANTS: A REVIEW

    About Authors:
    Hemant Rathod*, M.P.Khinchi, Dilip Agrawal, Natasha Sharma
    *Department of Pharmaceutics
    Kota College of Pharmacy,
    Kota, Rajasthan, India
    *hemant2787@gmail.com

    Abstract
    Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth without water. These products have staying power in the marketplace because they appeal to consumers and support increased compliance among users as well as provide effective life-cycle management. The principle challenge with orally disintegrating tablets (ODTs) is to develop tablet formulations that deliver rapid disintegration, pleasant mouth feel and high breaking force for tablet robustness. Superdisintegrants affect a range of formulation parameters; including the rate of disintegration, tablet breaking force, and mouth feel i.e. Polyplasdone XL-10 superdisintegrant provides optimal performance in ODT formulations.

  • AN OVERVIEW: MELT-IN-MOUTH TABLETS

    About Authors:
    Hemant Rathod*, Shakti Shekhawat, Jimit Shah, Parth Gandhi
    Department of Pharmaceutics,
    Kota College of Pharmacy, Kota, Rajasthan.
    *hemant2787@gmail.com

    Abstract
    Oral solid dosage form are more popular than other dosage form but suffer from problems like taste, solubility, bioavailability; so patient compliance. To improve patient compliance, melt in mouth tablets have emerged as an alternative to conventional oral dosage form. The aim is to provide the tablet that quickly melts upon contact with saliva and also provides a good mouth feel. The venture's latest technology, called Frosta™, involves tablet formulations that can melt in a patient's mouth as quickly in 10 seconds much faster than existing commercial products made by tablet press machines. Melt in mouth tablet disintegrate in saliva without need of drinking water within 15 to 60 seconds. There is easy administration to pediatric, geriatric & psychiatric patients.  They produce rapid onset of action with increased bioavailability. Free of the risk of suffocation due to physical obstruction when swallowed, thus offering improved safety. It has ability to provide advantages of liquid medication in the form of solid preparation. It can be manufactured with common methods such as Freeze drying, Moulding, Sublimation, Spray-Drying, Mass-Extrusion, Direct Compression and by using conventional equipment. Keeping in view of the advantages of the delivery system, rapidly disintegrating dosage forms have been successfully commercialized, and because of increased patient demand, these dosage forms are expected to become more popular.

  • A REVIEW ON HISTAMINE ANTAGONIST

    About Authors:
    Mahaveer Kabra*1, Sanjay Bhandari1,  Ami Sharma1, Reema Jain2
    Department of Pharmacology,
    1Kota College of Pharmacy, Kota
    2Bhupal Noble’s Institute of Pharmaceutical science, Udaipur
    *sanskarkabra@gmail.com

    Abstract:
    A histamine antagonist is an agent which serves to inhibit the release or action of histamine. Allergies are caused by an excessive response of the body to allergens, such as the pollen released by grasses and trees. An allergic reaction indicates an excessive release, of histamine by the body.Histamine is a natural chemical produced by the immune (disease-fighting) system of the body. The main action of histamine is related to allergies. An allergen is a substance that is not normally harmful, such as pollen, but which causes an overreaction by the immune system in some people.drugs show their action by binding with their specific receptor like H1-receptor antagonists are Diphenhydramine, Meclizine etc. H2-receptor antagonists Cimetidine, Famotidine. All antihistamines are reversible, competitive antagonists at histaminic (H1) receptors. They act by inhibiting binding of circulating histamine to its receptor site, but do not prevent histamine release. Administration of an antihistamine results in inhibition of respiratory, vascular, and gastrointestinal smooth muscle constriction, a decrease in histamine-activated secretions from salivary and lacrimal glands, and anti-inflammatory effects. Antihistamines also decrease capillary permeability, which reduces the wheal and flare response to an allergen, as well as diminishes itching. Competitive inhibition of histamine at H2 receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced. Antihistamines are used as treatment for allergies.

  • A REVIEW ON ABRUS PRECATORIUS

    ABOUT AUTHORS:
    Mahaveer Kabra*, Sanjay Bhandari, Natasha Sharma Raman Gupta.
    Department of Pharmacology,
    Kota College of Pharmacy, Kota. Raj.
    *sanskarkabra@gmail.com

    ABSTRACT:
    Abrus precatorius
    Linn (Fabaceae) Plant found all throughout the plains of India, from Himalaya down to Southern India and Ceylon. It is used medicinally in various country. The roots, leaves and seeds of the plant are used medicinally. Glycyrrhizin, Triterpene glycosides, pinitol and alkaloids such as abrine, hepaphotine, choline and precatorine are the principle chemical constituents of the plants. Traditionally leaves are used as aphrodisiac, tonic, remove biliousness, useful in eye diseases, cures leucoderma, itching, skin diseases and wounds. The root is considered emetic and alexiteric. Internally, the seeds are described as poisonous and useful in affections of the nervous system and externally used in skin diseases, ulcers and affections of the hair. Antifertility, Antithrombin, Aanthelmintic Activity, Antimalarial are some reported activity of Abrus precatorius Linn.

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