Miscellaneous Articles

Research is an important tool for the human society. It is used to demystify the unsolved enigma of the nature. Homo sapiens are the most intelligent creature who has ever dominated the earth by his Intellectual reasoning and capacity. As we are living in 21^st century which is known as modern age. So it is vital to do research to discard the age-old hypothesis and to establish clear/concise conceptions about a particular issue which can makes our lives safer in the planet.

Abstract
Food colourants have been much important in food product manufacturing. Food and color additives are strictly studied, regulated and monitored. Federal regulations require evidence that each substance is safe at its intended level of use before it may be added to foods. Furthermore, all additives are subject to ongoing safety review as scientific understanding and methods of testing continue to improve. A color additive is any dye, pigment or substance which when added or applied to a food, drug or cosmetic, or to the human body, is capable (alone or through reactions with other substances) of imparting color. FDA is responsible for regulating all color additives to ensure that foods containing color additives are safe to eat, contain only approved ingredients and are accurately labeled. Certified colors are synthetically produced (or human made) and used widely because they impart an intense, uniform color, are less expensive, and blend more easily to create a variety of hues. Color is added to food for one or more of the following reasons:
(1) to replace color lost during processing,
(2) to enhance color already present,
(3) to minimize batch-tobatch variations, and
(4) to color otherwise uncolored food.

a.Quality control of crude drugs material, plant preparations and finished products.
b.Stability assessment and shelf life.
c.Safety assessment; documentation of safety based on experience or toxicological studies.
d. Assessment of efficacy by ethnomedical informations and biological activity evaluations.

ABOUT AUTHOR:
Devesh Sharma
M.Pharm-DRA
School of Pharmaceutical Sciences, JNU, Rajasthan
Trainee, Chemist, Ind-swift labs ltd, Mohali, (punjab)
devesh.m.pharmdra@gmail.com

ABSTRACT:
Corrective and Preventive Action (CAPA)is a concept within Good Manufacturing Practice (GMP). CAPA focuses on the systematic investigation of discrepancies (failures and/or deviations) in an attempt to prevent their recurrence. To ensure that corrective and preventive actions are effective, the systematic investigation of the failure incidence is pivotal in identifying the corrective and preventive actions undertaken. CAPA is part of the overall quality management system.CAPA is of paramount importance to the FDA. According to FDA documents CAPA accounts for 30-50% of FDA-483 forms issued for non compliance.

About Authors:
Kapil Sharma^*, Priyanka Sharma^**
*M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
^**M.sc, Yaresun Pharmaceutical Pvt Ltd,
Rajasthan, India.

Aim: - To search Pharmaceutical medicine (New, Safe & Effective) to enhance health and benefits of patients & community.

Trends:-Usually search a pharmaceutical medicine is starting from “Drug Discovery and Drug Development” (D4) or Pharmaceutical R&D.
D4 is very long, very costly and very complex process, so mostly companies put together D4 plan. Drug Discovery and Drug Development is the treds of searching a Pharmaceutical medicine

MOLECULES INVOLVED IN REGULATION OF STEM CELL DIFFERENTITIATION
Cell adeshive molecule E_cadhedrin which replaces oct 4signalling molecule there by converting normal somatic cell into pluripotent

About Authors:
S Hamza*¹, Dr Tanveer Aalam², Dr Asma^3
1*  Assistant Professor, Department of Pharmacology,
Shree M V Shah Pharmacy college,
Gajan, Modasa: 383315, Gujarat.
² Department of Emergency Medicine,
Apollo hospitals International Ltd,
Bhat GIDC estate,  Gandhinagar: 382428, Gujarat.
³ Medical Officer, Civil Hospital,
Ahmadabad: 380 002. Gujarat, India

ABSTRACT:
India suffers from the highest number of deaths - around 1,05,000 in absolute terms annually- due to road accidents in the world owing to poor infrastructure and dangerous driving habits according to the World Health Organisation¹. Calling road fatalities an "epidemic" that will become the world's fifth biggest killer by 2030². It is said that 90% of deaths on the world's roads occur in low and middle-income countries (21.5 and 19.5 per lakh of population, respectively) though they have just 48% of all registered vehicles.

Stevia rebaudianais a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. Leaves of this plant produce zero calorie, high potency sweetener and substitute to sucrose, being about 300 times sweeter than sucrose. The compounds, named stevioside and rebaudiocide give stevia its taste. In India number of diabetic people in the age group of 25-45 is about 15% and is also increasing at an alarming pace. In addition, India is the largest consumer of sugar in the world. So stevia is attaining attention in Indian market as a healthy alternative sweetener to sugar. Stevia has no calcium cyclamate, no saccharim, no aspartame and no calories. It is safe for diabetics, as it does not affect blood sugar levels and have no neurological or renal side effects.