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Clinical courses

  • EFFECT OF ASCORBIC ACID ON DISSOLUTION STABILITY OF RIFAMPICIN IN MARKET FIXED DOSE COMBINATION PRODUCTS FOR TUBERCULOSIS

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS
    Subashini Rajaram, Abirami Murugan, Nidhina Raj C.M
    Swamy Vivekanandha College of Pharmacy, Namakkal, Tamilnadu, India.
    Life Pharmacy, Al Barsha, Dubai-UAE
    subababu.r@gmail.com

     

    ABSTRACT
    Degradation of rifampicin (RIF) to insoluble and poorly absorbed 3-Formyl rifamycin SV (3-FRSV) in acidic environment is a major concern which leads to reduction in the bioavailability of RIF and is further influenced by the presence of isoniazid (INH) in the stomach after ingestion. It is recommended that addition of ascorbic acid (ASC) in dissolution medium, in plasma as antioxidant to stabilize RIF from degradation and also daily intake of ASC to control tuberculosis (TB).Though the effect of ASC on fixed dose combination (FDC) products has not been traversed and hence examined in the present study.  The rate of degradation of RIF to 3-FRSV in the presence of ASC in dissolution medium (0.1 N HCl) on market formulations was estimated by Dual Wavelength UV–Vis. spectrophotometry (DW spectrophotometry) and High performance liquid chromatography (HPLC) method. Addition of ASC in FDC formulations lowered significantly formation of 3-FRSV or degradation of RIF as compared to that without ASC in in-vitro. Our study proposed that co-package of ASC with fixed dose combination products (FDC) can protect RIF degradation in the acidic environment and in-vivo investigation needed to predict the bioavailability of RIF in FDC products in the presence and absence of ASC for effective control of TB.

  • Required Executive documentation - Easy Reach Management Consultants

    Easy Reach Placement, Established  is a excellent brand equity with a premium image amongst HR community at many Indian Giants and Blue chip Multinational Conglomerates in catering manpower placement services for our valued patrons to manage their Human Assets. In the era of Hi-tech Millennium & Rapid Globalization with prevailing competition, sourcing of Right Candidate for the Right Job at Right Time at Right Cost. Easy reach is making significant Contribution in terms of meeting our Valued Clients quality manpower requirements ranging from Junior Level to Corporate Heads.

    Post : Executive documentation

  • INSPIRATION FROM REAL LIFE HEROES

    Inspired and moved to share  below the essence of a true story which has unfolded in our own country in the recent past and in our own midst:

  • Job as Manager Drug Safety in Icon Clinical Research

    ICON is a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries. We specialize in the strategic development, management and analysis of programs that support Clinical Development – from compound selection to Phase I - IV clinical studies ICON enjoys a strong reputation for quality and is focused on staff development. We make it our mission to attract the most diverse and creative minds into the business and we continually strive to provide opportunities for our people to excel, grow and build a great career. We understand that our greatest asset is the skills and talents of our people and they are truly what set us apart.

    Post: Manager Drug Safety

  • PharmaTutor Magazine - September 2016 is released | Subscribe today

  • Drug Inspector Question Paper 2009 -TNPSC

    1. Which of the following trademarked sustained release systems are based on encapsulated drug particles that will dissolve at various rates ?  
    I.   Sequels
    II.   Spansules
    III.  Extentabs.
    Of these
    A)  I only
    B)  III Only
    C) I and II
    D) I, II, and III

  • Career opportunity for Asst manager / Executive at Sun Pharma

    Sun Pharma ranks amongst India's largest pharma companies We’ve built a reputation for speciality therapy leadership and faster- than-industry growth over the last 30 years. From a modest beginning with five people, our team today exceeds 13,000 and growing, put manufacturing base now spans 25 sites across the world. With a market cap of over $ 16 billion, we’re also India’s most valued pharma brand. To keep pace with our growth plans, we require for our Formulation manufacturing plant at Halol (Near Baroda):

    Post: Asst manager / Executive

  • Recruitment for Drug Inspector (25 Posts) in Food and drug administration department | Govt Job

    Candidates after submitting their applications through On-Line shall send photocopies of their all academic/required documents regarding their claims along with print out of On-Line application form within 21 days from the last date of submitting the applications (date 03rd October, 2016 till 5.00 O' Clock) on the working day through registered/Speed Post or Personally in the office of the Commission.

  • Required for Manager- Infrastructure Government Healthcare in KPMG

    KPMG international operates as a network of member firms offering audit, tax and advisory services. We work closely with our clients, helping them to mitigate risks and grasp opportunities. Member firms' clients include business corporations, governments and public sector agencies and not-for-profit organizations. They look to KPMG for a consistent standard of service based on high order professional capabilities, industry insight and local knowledge.

  • Walk in at Thomson Reuters for fresh B.Pharm, M.Pharm, M.Sc as Associate Research Analyst

    Thomson Reuters is the leading source of intelligent information for the world's businesses and professionals, providing customers with competitive advantage. Intelligent information is a unique synthesis of human intelligence, industry expertise and innovative technology that provides decision-makers with the knowledge to act, enabling them to make better decisions faster. Through its more than 50,000 people across 93 countries, Thomson Reuters delivers this must-have insight to the financial, legal, tax and accounting, scientific, healthcare and media markets, and is powered by the world's most trusted news organization.

    Post: Associate Research Analyst -JREQ066975

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