GATE PY – 1992 Question Paper

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2.1 The antibiotics mentioned below are obtained from the organisms listed from a to e. match them.
(1) Neomycin (a) streptomyces fradiae
(2) Gentamycin (b) micromonospora purpurea
(3) Bacitracin (c) streptomyces tenebrarius
(4) Tobramycin (d) bacillus subtilis
(e) bacillus polymyxa

2.2. Given below is a list of medicinal plants. Match them correctly with the list of constituents given in a to e.
(1) Holarrhena antidysenterica (a) Conessine
(2) cymbopogan flexuous (b) Citral
(3) Urginea indica (c) Mucilage
(4) Linum usitatissimum (d) Cocaine
(e) Scillarenin

2.3. The following drugs are included under the schedules listed in a to e. match them.
(1) Meprobamate (a) Schedule E
(2) Poisonous drugs (b) Schedule F, F
(3) Ophthalmic preparations (c) Schedule C and C
(4) Biological and special products (d) Schedule X
(e) Schedule Q

2.4. Following drugs contain 2 hydroxyl groups each. Nature of these hydroxyl groups are indicated in a to e. Match them correctly.
(1) Morphine (a) Alcoholic but one 1° another 2°
(2) Chloramphenicol (b) Alcoholic and both 1°
(3) Apomorphine (c) Both phenolic
(4) Cortisone (d) One alcoholic and one phenolic
(e) Alcoholic but 1° and another 3°

2.5. The following drug molecules contain heterocyclic rings listed in a to e. match them correctly.
(1) Haloperidol (a) Pyrimidine
(2) Sulphadiazine (b) Pyridine
(3) Amiloride (c) Piperidine
(4) Pheniramine (d) Pyrazine
(e) Pyridazine

2.6. Following drugs exhibit their action by enzyme inhibition. Enzymes are listed in a to e. Match them correctly.
(1) Captopril (a) ß – lactamase
(2) Clavulanic acid (b) MAO
(3) Pargyline (c) Monooxygenase
(4) Methozolamide (d) Carbonic anhydrase
(e) ACE

2.7. Following preparations are assayed by biological techniques using the animal or its parts listed in a to e. match them correctly.
(1) Cod liver oil (a) Sheep blood
(2) Heparin injection (b) Rabbit
(3) Oxytocin injection (c) Rat
(4) Insulin injection (d) Anaesthetized chicken
(e) Cat

2.8. Following I.P. assays involve the principles listed in a to e. Match them.
(1) Sodium chloride injection (a) Titration with N/10 iodine
(2) Trimethoprim (b) Oxidation involving 2 : 6 dichloropheol indophenol
(3) Analgin tablets (c) Argentometry
(4) Ascorbic acid (d) Non-aqueous
(e) Acidimetry

2.9. Given below are some antihypertensive mechanisms. Drugs which are closely associated with these mechanisms of action are listed in a to
Match them correctly?

(1) Ganglion blocking             (a) Methyl dopa
(2) Catecholamine depletor    (b) Hydralazine
(3) False neurotransmitter      (c) Reserpine
(4) Direct action on arterioles (d) Mecamylamine
                                        (e) Veratrum alkaloids

2.10. Listed are Vitamins. Their associations with certain coenzymes are well known. The names of coenzymes are given in a to e. match them correctly.
(1) Thiamine           (a) Co-carboxylase
(2) Riboflavin          (b) Co-enzyme A
(3) Panothenic acid  (c) NAD
(4) Nicotinamide       (d) FAD
                            (e) ATP

2.11. Listed are some of the crude drugs which are tested for the active constituents by the tests mentioned in a to e. Match them correctly.
(1) Cinchona Bark         (a) Fluorescene test
(2) Nux vomica seeds    (b) Keller Killiani
(3) Digitalis leaves        (c) Borntrager‘s test
(4) Senna leaves          (d) Mayer‘s test
(e) Sham‘s test

2.12. Listed are some of the common volatile oils. Their active constituents are given in a to e. Match them correctly.
(1) Peppermint oil    (a) (+)-Limonene
(2) Turpentine oil     (b) 1:8-Cineole
(3) Eucalyptus oil     (c) a -Pinene
(4) Lemon oil           (d) (-)-Menthol
                            (e) (+)-Menthol

2.13. Match the each pair with the type of a structural relationship they exhibit.
(1) (R) and (S) Naproxen (a) Tautomers of one another
(2) Dilactim and Monolactim (b) Diastereomers of one another form of Barbituric acid
(3) Quinine and Quinidine (c) Non-superimposable mirror images of each other
(4) Eclipsed and staggered form (d) Superimposable mirror images of each other of phenothiazine about side chain carbon œcarbon bond
(e) Conformational isomers of one another

2.14. Various polymers used in pharmacy are given. Match with the respective monomers a to e.
(1) Carbopol           (a) Methacrylate ester
(2) Eudragits          (b) Ethylene
(3) Polyethylene     (c) Ethylene glycol
(4) Polycarbonate    (d) (Bis-phenol + phosgene)
(e) Acrylic acid

2.15. Following are some naturally occurring substances. They are classified under different categories which are listed in a to e. match them correctly.
(1) Prostaglandins (a) Opioids
(2) Codeine (b) Eicosinoids
(3) Angiotensin II (c) Corticoids
(4) Strophanthidin (d) Peptide
(e) Cardinolide

2.16. Following are some of the analytical instruments. Their important components are listed in a to e. Match them correctly.
(1) HPLC                                         (a) Monochromator
2) IR double beam spectrophotometer   (b) Dropping mercury electrode
(3) Karl-Fischer titrator                      (c) Isocratic pump
(4) Polarograph                                 (d) Platinum electrode
                                                     (e) Polariser

2.17. The hard gelatin capsule sizes are mentioned in their number. Their approximate capacity are listed in a to e. Match their correct volume.
(1) 0 (a) 0.10 ml
(2) 1 (b) 0.15 ml
(3) 3 (c) 0.30 ml
(4) 5 (d) 0.55 ml
        (e) 0.75 ml

2.18. Listed are some of the commonly used drugs. Their pharmacological actions are listed in a to e. match them.
(1) Aspirin               (a) Rises body temperature
(2) Acetaminophen   (b) Non-analgesic anti-inflammatory
(3) Phenylbutazone   (c) Non-anti-inflammatory analgesic
(4) Probenacid         (d) Increases depth of respiration
                             (e) Increases fluid retention

2.19. Match the preservations/antioxidants listed in a to e for the preparations mentioned below.
(1) Anaesthetic ether           (a) Chloroform
(2) Formaldehyde                 (b) Ethylenediamine
(3) Injection of Adrenaline     (c) Paraformaldehyde
(4) Injection of Aminophylline (d) Sodium bisulphate
                                        (e) Alcohol

2.20. In communition, certain type of materials listed in a to e are not suitable for the mills mentioned below. Match them.
(1) Cutter mill          (a) Soft material
(2) Hammer mill        (b) Adhesive material
(3) Revolving mill      (c) Friable material
(4) Fluid energy mill   (d) Liquefiable material
                             (e) Abrasive material

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