Work as Senior Research Investigator at Syngene International

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Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area. Based in Bangalore, Karnataka, the Company is situated in a 90 acre Special Economic Zone with over 100000 sq. mt of built up facilities.

Post : Senior Research Investigator-Antibody Engineering

Job Description : 
• Independently perform Antibody gene cloning, engineering, designing and generation of Bi-specifics, Multi-specifics, CAR-T molecules etc.
• Engineered antibody expression and purification from various expression systems and QC by various methods.
• Conducting various in vitro assays using the purified complex antibodies.
• Complex antibody purification process development and optimization.
• Guide and train research scientists in the team at various levels.
• Prepare detailed reports for sharing with clients and attend telecons.
• Provide technical and scientific input in project design and proposal writing.
• Resource management for the expression & purification team.
• Improve lab efficiency and streamlines the operational processes to increase productivity.
• Analyze operational problems, identify solutions, and implement corrective actions.
• Contribution to inventory keeping, general laboratory maintenance and safety.
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.

Candidate Profile
• PhD in Biotechnology or related field
• 3-6 Years Post Qualification
• Relevant antibody-based research experience in biotech, pharma or academia - recombinant antibody generation, Engineering, CAR-T designing etc.
• Proven strong technical expertise in protein purification including complex antibodies from expression systems (Mammalian, E. coli, Insect cells and Pichia) using various chromatographic techniques.
• Expertise in analytical techniques like Spectrophotometry, SDS-PAGE, Western blotting, SE-HPLC, BIAcore, Octet, FACS etc.
• Understanding of Mass spectrometry, protein sequencing etc.
• Understanding of Functional activity assays for antibodies in vitro and in vivo.
• Knowledge of Basic bioinformatics tools-Handling of Molecular Biology analysis tools like Sequencher, Vector NTi, SnapGene etc.
• Excellent verbal and written communication and interpersonal skills.Ability to work independently as well as in a team environment.
• Ability to manage multiple projects in parallel and coordination of internal and external resources is essential.
• Strong organizational, detail-orientation, prioritization and multi-tasking skills.
• Attention to detail, strong analytical skills and ability to work under strict timeline

Additional Information
Qualification : Ph.D
Location : Bangalore
Industry Type : Pharma/ Healthcare/ Clinical research
Functional Area : Antibody Engineering
Req Id : 12265
End Date : 30th July, 2020

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