RESEALED ERYTHROCYTES - AS A CARRIER
ROUTE OF ADMINISTRATION
Intra peritoneal injection reported that survival of cells in circulation was equivalent to the cells administered by i.v injection .They reported that 25% of resealed cell remained in circulation for 14 days they also proposed this method of injection as a method for extra vascular targeting of RBCs to peritoneal macrophages. Subcutaneous route for slow release of entrapped agents. They reported that the loaded cell released encapsulated molecules at the injection site.(42- 44)
These are specially engineered vesicular systems that are chemically cross-linked to human erythrocytes’ support upon which a lipid bilayer is coated. This process is achieved by modifying a reverse-phase evaporation technique. These vesicles have been proposed as useful encapsulation systems for macromolecular drugs.(45-46)
These are prepared by extrusion of erythrocyte ghosts to produce nm. Daunorubicin was covalently conjugated to nanoerythrosomes using gluteraldehyde spacer. This complex was more active than free daunorubicin alone.(47-48)
The concept of employing erythrocytes as drug or bioactive carrier still need further optimization. A large amount of valuable work is needed so as to utilize the potentials of erythrocytes in passive as well as active targeting of drugs in diseases like cancer. For the present, it is concluded that erythrocyte carriers are most effective in novel drug delivery systems considering their tremendous potential. Genetic engineering aspects can be coupled to give a newer dimension to the existing cellular drug carrier concept. Main suggestion for future study is that by using RBCs as carrier through we can transplant steroids and hormones to the targeting site by reducing their side effects.
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