MODIFIED LIPID VESICLES, ETHOSOMES AND INVASOMES: POTENTIAL CARRIERS FOR TRANSDERMAL DRUG DELIVERY

Pharma Admission

pharma admission

 

CONCLUSION:
Extensive studies are reported to enhance efficiency of lipid vesicles on dermal or transdermal drug delivery. However, most of the studies focused on in vitro or laboratory experiments. Confirmation of lipid vesicles for clinical use may extend their applicability. Although liposomes are theoretically thermodynamically stable, conquering the stability problem during storage is an important issue. The instability of liposomes can cause leakage of encapsulated drugs from the vesicles and aggregation and/or fusion to form larger vesicles. The classic nano-sized vesicles may not exhibit their benefits after aggregation. Advanced attempts have been successfully applied in the laboratory, many problems need to be overcome and investigations may be modified for the commercial patents and products in the future. The valid preparation procedures from laboratory scale to mass production are also important for resolving these realistic difficulties is the challenge and mission for future development of new products and formulations of lipid vesicular systems.

ACKNOWLEDGEMENTS:
The authors thank Dr. M. S. Ranawat and Dr. C.S. Chauhan, B. N. College of Pharmacy, Udaipur, Rajasthan for their technical assistance, valuable suggestions and comments during the preparation of this review article.

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