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Clinical courses

  • To Evaluate Anti-inflammatory Activity of leaves of Lawsonia inermis in rats

    About Authors:
    ATUL KABARA*, RUCHI THAKKAR, NITIN PATEL
    Department of Pharmacology
    G.H.B Pharmacy college,
    Aniyad,Gujarat
    *atul.kbr@gmail.com

    ABSTRACT:
    Lawsonia inermiscommonly known as Henna is a perineal herbaceous plant belonging to family Lauraceae. Traditionally it has been used to treat skin disease, dysentery, bronchitis, anemia and inflammation . The aim of present study was to investigate the anti-inflammatory activity of aqueous extract of Lawsonia leaves in rats. Aqueous extract was administered at a dose of 250mg/kg and 500mg/kg.

  • PHARMACODYNAMIC INTERACTION OF FENUGREEK LEAVES EXTRACT WITH FLUVASTATIN IN DIABETES INDUCED VASCULAR DYSFUNCTION

    About Authors:
    ATUL KABRA* , PREMAL KAPADIA
    Department of Pharmacology,
    G.H.B Pharmacy college,
    Aniyad, Gujarat

    * atul.kbr@gmail.com

    ABSTRACT:
    The cardiovascular risk factors were significantly abnormally altered in diabetic rats when compared to normal control. The present study FLEt with low dose of OHA’s indicates the significant improvement in endothelial dependent vasodilatation because the percentage relaxation produced by acetylcholine was more significant when these groups were compared with diabetic control.However all the treated groups restored these changes significantly to normal conditions in diabetic rats when compared to diabetic control. The combined therapy of FLEt and Fluvastatin was found to be significantly effective. Moreover, this combination was also found to demonstrate synergistic behavior than pioglitazone plus fluvastatin.
    We conclude that of preventive therapy with combination of FLEt with OHA’s (low dose) may prevent the endothelial dysfunction in diabetic patients (prediabetic state) due to free radical scavenging activity, metabolic control.

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  • EVALUATION OF ANTIULCER ACTIVITY OF FRUIT EXTRACT OF Ziziphus jujuba IN RATS

    About Author:
    ATUL KABRA*, NITIN PATEL
    Department of Pharmacology
    G.H.B Pharmacy college,
    Aniyad, Gujarat

    * atul.kbr@gmail.com

    ABSTRACT:
    The antiulcer effect of aqueous fruit extract of Zizizphus jujuba was studied in ethanol induced ulcer model in rats. The extract dose of 50 mg/kg, 100mg/kg, 200 mg/kgproduced significant inhibition of gastric lesion induced by ethanol. The extarct reduced ulcerative lesion, gastric volume, total acidityin ethanol induced ulcer model.The result obtained suggesting that extract possesses significant antiulcer activity. 

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