You are herePharma News
ICMR SPONSORED One Day National Seminar On "BIOAVAILABILITY ENHANCEMENT TECHNIQUES & REGULATORY ISSUES" 27th October, 2012, Saturday
Dr. Martin Edelman, professor of medicine at the University of Maryland School of Medicine and director of Solid Tumor Oncology at the University of Maryland Greenebaum Cancer Center, comments on the results of a study published in The Lancet, which found that aspirin was successful in preventing the occurrence of solid tumors for a variety of cancers, including lung cancer, esophageal cancer and colorectal cancer. Dr. Edelman provides a brief overview of the study and provides some perspective on the implications of the study results for cancer prevention guidelines in the future.
“Recent acquisition of Indian generic drug companies by MNCs has increased fears that the price of low-cost generic drugs will rise in India. The buy-outs will reduce domestic availability of many essential medicines; point out an internal assessment of the health ministry, Government of India. It is ironic that despite India supplying quality generic drugs around the world, the country has concerns about sufficient domestic drug supply and vaccines security. With the increasing acquisition of Indian companies by overseas drug corporations, there is a pressing need to rethink India’s drug strategy”. This statement was released by government of India before few months. Now what global honchos think about India?
Research is an important tool for the human society. It is used to demystify the unsolved enigma of the nature. Homo sapiens are the most intelligent creature who has ever dominated the earth by his Intellectual reasoning and capacity. As we are living in 21st century which is known as modern age. So it is vital to do research to discard the age-old hypothesis and to establish clear/concise conceptions about a particular issue which can makes our lives safer in the planet.
S Hamza*1, Dr Tanveer Aalam2, Dr Asma3
1* Assistant Professor, Department of Pharmacology,
Shree M V Shah Pharmacy college,
Gajan, Modasa: 383315, Gujarat.
2 Department of Emergency Medicine,
Apollo hospitals International Ltd,
Bhat GIDC estate, Gandhinagar: 382428, Gujarat.
3 Medical Officer, Civil Hospital,
Ahmadabad: 380 002. Gujarat, India
India suffers from the highest number of deaths - around 1,05,000 in absolute terms annually- due to road accidents in the world owing to poor infrastructure and dangerous driving habits according to the World Health Organisation1. Calling road fatalities an "epidemic" that will become the world's fifth biggest killer by 20302. It is said that 90% of deaths on the world's roads occur in low and middle-income countries (21.5 and 19.5 per lakh of population, respectively) though they have just 48% of all registered vehicles.
A COMPARATIVE RELEASE STUDY OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE FROM DIFFERENT VEHICLES BY USING DIFFERENT CHEMICAL ENHANCERS
RANI SHALU1*, SAROHA KAMAL1, NANDA SANJU2
1Institute of Pharmaceutical Sciences,
Kurukshetra University, Kurukshetra 136119, Haryana, India.
2Department of Pharmaceutical Sciences,
MDU, Rohtak 124001,
The aim of the present study was to investigate the in-vitro release properties of Ziprasidone hydrochloride monohydrate from different topical vehicles. By the unique advantages over the traditional drug delivery, transdermal drug delivery is becoming increasingly important and has got a vital interest in pharmaceutical industries. An in vitro release experiment was designed to reveal the rate of release of ziprasidone hydrochloride monohydrate from four different topical vehicles: (i) cream; (ii) a gel; (iii) an ointment (iv) pronoisomal gel. In vitro release of ziprasidone hydrochloride monohydrate from the four bases was monitored spectrophotometrically at a wavelength of 318 nm. In vitro release study results showed that the release of drug from vehicles ranks according to the following order: gel> proniosomal gel> cream> ointment. Gel base showed considerably higher drug release than other vehicles. Five types of chemical enhancers was used in the study and among them tulsi oil was the best enhancer. As we increase the concentration of chemical enhancer the release of drug also increases. By monitoring and attempting to explain the many possible reasons for the different rates of drug release from the vehicles, it was hope that the experiment would confer essential information concerning factors affecting the release of drugs from topical formulations.
Stevia rebaudianais a well known medicinal herb contains antibacterial, antifungal, anti-inflammatory, anti-viral, anti-yeast, cardiotonic diuretic and hypoglycaemic properties. This herb has been used in Ayurveda in India since centuries. Stevia is a perennial herb belonging to the family Asteraceae, is one of the most valuable tropical medicinal plant. Leaves of this plant produce zero calorie, high potency sweetener and substitute to sucrose, being about 300 times sweeter than sucrose. The compounds, named stevioside and rebaudiocide give stevia its taste. In India number of diabetic people in the age group of 25-45 is about 15% and is also increasing at an alarming pace. In addition, India is the largest consumer of sugar in the world. So stevia is attaining attention in Indian market as a healthy alternative sweetener to sugar. Stevia has no calcium cyclamate, no saccharim, no aspartame and no calories. It is safe for diabetics, as it does not affect blood sugar levels and have no neurological or renal side effects.
Tarun Patel, Prof. Dr. Vipin Kukkar, Amit Patel
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
It is a product which is used for improvement of appearance of human body by applying it externally on human body. For better results and minimizing risk of adverse reaction of cosmetic products on human body we have to check out and maintain quality of cosmetic products during its manufacturing. And also required some safety parameters for manufacturing of cosmetic products. In this review article we discussed briefly about quality and safety parameters during manufacturing of cosmetic products.
Mobile technology is defined as a term which includes all types of communications performed by mobile. These days mobile health or mHealth is an emerging field which uses mobile technology to deliver better healthcare services and also useful in health researches which helps to meet the global health challenges of today.
Sreedhar Reddy C
M.Pharm, Department of Pharmaceutics,
Vasavi Insitute of Pharmaceutical Sciences,
Vasavi Nagar, Peddapalli (V), Kadapa (dist),
In this study, transdermal patches containing Itraconazole were prepared using different ratios of polyvinylpyrrolidone (PVP) and Hydroxy propyl methyl cellulose (HPMC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and HPMC was casted on a polyvinylalcohol backing membrane that was previously dried at 600C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by IR spectroscopy have absence of any incompatibility. In vitro permeation studies were performed across skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/HPMC, 5:1) and F5 (PVP/HPMC, 1:5) were chosen for further in vivo experiments. The anti inflammatory effect and a sustaining action of Itraconazole from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. Hence, it can be reasonably concluded that Itraconazole can be formulated into the transdermal matrix type patches to sustain its release characteristics.