You are hereF&D
YASWANTH ALLAMNENI1*, NAVYA ALLAMNENI2, R AMARNATH1, T RAMASWAMY CHOWDARY1, V SATYANARAYANA1, K VENKATESWARA RAO1
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar, Andhra Pradesh – 509228.
2Department of Pharmaceutical Technology, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Guntur,
Andhra Pradesh, India.
The main aim of this article was to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. Orally disintegrating tablets are also called as orodispersible, quick disintegrating, mouth dissolving, fast disintegrating, rapid dissolving tablets, porous tablets, and rapimelts.Orally disintegrating systems have carved a niche amongst the oral drug delivery systems due to the highest component of compliance they enjoy in patients especially the geriatrics and pediatrics. However, of all the above terms, USP approved these dosage forms as ODTs. These tablets are distinguished from conventional sublingual tablets, lozenges, and buccal tablets which require more than a minute to dissolve in the mouth. According to the recently issued draft guidance for Industry of orally disintegrating tablets, FDA specifically recommends that, in addition to the original definition for an ODT, ODTs be considered solid oral preparations that disintegrate rapidly in the oral cavity, with an in vitro disintegration time of approximately 30 sec or less according to the united states pharmacopoeia (USP) disintegration method or alternative. ODTs release drug in the mouth for absorption through local oromucosal tissues and through pregastric (e.g., oral cavity, pharynx, and oesophagus), gastric (i.e., stomach) and post gastric (e.g. .small and large intestines) segments of the gastrointestinal tract.
Multiple vacancies in AKUMS DRUGS & PHARMACEUTICALS | Require B.Pharm, M.Pharm, B.Sc, M.Sc in DRA, QA, AR&D, FR&D, IPR, stores and more
AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand giving employment to more than 2000 people.
More M.Pharm / M.Sc Freshers invited as Associate Scientist - Analytical in Novartis | Fresher - 3 posts
A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.
Kapil Sharma*, Priyanka Sharma**
*M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
**M.Sc, Yaresun Pharmaceutical Pvt Ltd,
Pellets are spheres of varying diameter depending on the application and the wish of the producer. Applications are found not only in the pharmaceutical industry but also in the agribusiness (e.g., fertilizer, fish food) and in the polymer industry.
In the pharmaceutical industry, Pellets can be defined as small, free-flowing, spherical particulates manufactured by the agglomeration of fine powders or granules of drug substances and excipients using appropriate processing equipment. The term also has been used to describe small rods with aspect ratios of close to unity.
Opportunity for Science / Pharma / Engineering Graduates to work in Canada & USA by Taurus Biotech - consultancy firm | 10 posts
Taurus Biotech is representing a consultancy firm Headquartered in Toronto, Canada, which serves the pharmaceutical, medical devices and biotechnology industries in North America and internationally since 1997, in the field of drug discovery, strategic planning to process scale up having esteemed clientele like Pfizer, Cibavision,Sanofi Pasteur,Wyeth,Biovail,Apotex,Schering-Plough and Canadian Blood services etc.
Post: Trainee/Executives - 10 posts
Multiple Vacancies in ARABIO - Saudi Arabia | Job as Production Manager, QA-QC Asst Manager, Formulation Supervisor, Quality Control Analyst, Quality Assurance Officer, Lypholization Technician
Arabio is a biopharmaceutical company specialized in human vaccines, plasma products, and other biopharmaceuticals.
Arabio is the first biopharmaceutical company in the Gulf Cooperation Council (GCC). The size and scope of activities intended to be made in Arabio would make Arabio the first biological company of its kind in the Middle East.