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  • A REVIEW ON TARGETED DRUG THERAPY FOR CANCER: A NOVEL DRUG DELIVERY APPROACH

    About Author:
    Kabita Banik
    B.pharm;(WBUT) BCDA College of pharmacy &Technology;
    M.pharm(BPUT) Dadhichi college of pharmacy.
    banikkabita64@gmail.com

    Abstract:
    New cancer targeted therapies that make use therapeutic antibodies or small molecules have made treatment more tumor specific and less toxic. Nevertheless, there remain several challenges to the treatment of cancer, including drug resistance, cancer stem cells, and high tumor interstitial fluid pressure. In many solid tumors, for example, increased interstitial fluid pressure makes the uptake of therapeutic agents less efficient. One of the most promising ways of meeting such challenges is ligand-targeted therapy that may be used to make targeting more specific and carry higher dosages of anti-cancer drug to tumor tissue.

  • ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLOPIDOGREL BY DERIVATIVE SPECTROSCOPY (FOURTH ORDER)

    About Authors:
    Gunjan Kalyani*, Vishal S. Deshmukh, Pranita Kashyap, Ram D. Bawankar, Yogesh Vaishnav, Deepak Biswas
    Shri Rawatpura Sarkar Institute of Pharmacy,
    Behind power grid, Kumhari, Durg, Chhattisgarh
    *kalyani.gunjan@yahoo.in

    Abstract
    Clopidogrel bisulfate is an inhibitor of adenosine diphosphate (ADP)-induced platelet aggregation acting by direct inhibition of ADP binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of clopidogrel in pure form. For the estimation of clopidogrel, solvent system employed was 0.1 N HCl and wavelength of detection (λdet) was 284.3 nm for fourth order derivative spectroscopy. The linearity was obtained in the range 42 – 336 µg/ml. The limit of detection is 6.7 µg/ml and limit of quantification was fund to be 20.4 µg/ml. Obtained results showed that there is minimum intra day and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claim, thus suggesting the validity of the method and non-interference of formulation excipients in the estimation. Fourth order derivative spectroscopic method is simple, rapid and reproducible and further it can be used for the analysis.

  • ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CANDESARTAN CILEXETIL BY CHROMATOGRAPHIC TECHNIQUE (RP-HPLC).

    About Authors:
    Gunjan Kalyani*, Vishal S. Deshmukh, Pranita Kashyap, Ram D. Bawankar, Yogesh Vaishnav, Deepak Biswas
    Shri Rawatpura Sarkar Institute of Pharmacy,
    Behind power grid, Kumhari, Durg, Chhattisgarh
    *kalyani.gunjan@yahoo.in

    Abstract:
    A simple, rapid and precise and accurate RP-HPLC method was developed for the estimation of candesartan. The method involves a simple technique using Irbesartan as internal standard. HPLC separation was achieved using C18 Intersil column (256 x 4.6 id) with an isocratic mobile phase composed of selected methanol: 10 mM Phosphate buffer [75:25 % v/v. pH 3.0] at a flow rate of 1.0 mL/min with UV detection was performed at 256 nm. The retention time of candesartan and internal standard was found to be 1.96 and 3.33 min respectively. The assay was validated for the parameters like accuracy, precision, robustness and system suitability parameters. The method was validated over a linear test concentration range of 80 - 120%. The recovery of the method was in between 99.0 - 101.0%. The proposed method was found to be accurate, precise, selective and rapid and it can be useful in the routine analysis for the determination of candesartan cilexetil in pharmaceutical dosage form.

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  • HERBAL ALTERNATIVES TO ASTHMA

    Aabout Author:
    Dhirendra C. Patel*
    Master of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology,
    S.K. Patel College of Pharmaceutical Education and Research, Ganpat University,
    Kherva, Mehsana, Gujarat, India.
    dhiren.pharmacy@gmail.com

    Abstract:
    Herbal medicines are very popular in treatment of the asthma in the modern era because of lots of benefits of it like less cost, less side effects, easily available etc. Herbal alternatives to asthma are better way for treatment of asthma. Various herbal medicines recognize that immune system functioning can play a vital role in helping to control the symptoms of asthma and strengthen the body's defenses against environmental allergens. Herbal medicines like ephedra, ginger, chamomile, elderberry, licorice, mullein, stinging nettle etc are very beneficial in asthma. Scientists have found evidence to support herbal's wide range of medicinal actions. These actions include the lowering of cholesterol levels, relief for allergies and asthma etc. Herbs have been used by people for longer than we have been keeping written record. Originally they were found in the wild by the gatherers and used for lots of different things. I light here, the use of herbals in asthma. It aims to tap into the body’s own healing mechanism by transforming the “triggers” of such attacks as part of the remedy. Opinions of different authors are saying that herbal medication is better way for asthma treatment.

  • ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF SALMETEROL BY UV SPECTROSCOPY

    About Authors:
    Gunjan Kalyani*, Vishal S. Deshmukh, Pranita Kashyap, Yogesh Vaishnav, Ajit Kumar Pandey
    Shri Rawatpura Sarkar Institute of Pharmacy,
    Kumhari, Durg, Chhattisgarh.
    kalyani.gunjan@yahoo.in, rvg_54767@yahoo.co.in*

    Abstract:
    The IUPAC Name of Salmeterol is (RS)-2-(hydroxymethyl)-4-{1-hydroxy-2-[6-(4-phenylbutoxy) hexylamino]ethyl}phenol. Salmeterol is a prescription drug that is used for treating airway spasms in people with asthma or chronic obstructive pulmonary disease (COPD). By relaxing the muscles around the airways to allow more air into and out of the lungs, the medication can help prevent asthma attacks from occurring.Salmeterol comes in the form of an inhalation powder and is generally used twice a day. Present research work deals with UV spectrophotometric method for the estimation of salmeterol in pure form. For the estimation of salmeterol, solvent system employed was ethanol and wavelength of detection (λdet) was 252 nm. The linearity was obtained in the range 6 – 14 µg/ml, with a regression coefficient, R2= 0.999. The LOD & LOQ were found to be 4.99 µg/ml and 14.24 µg/ml respectively. Obtained results showed that there is minimum intra day and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and non-interference of formulation excipients in the estimation.

  • A REVIEW: PARENTERAL CONTROLLED DRUG DELIVERY SYSTEM

    About Author:
    Mahek Goel

    Shri Baba Mastnath Institute of Pharmaceutical Science & Research
    Asthal Bohar, Rohtak, Haryana (124001)
    mahekgoel10@gmail.com

    ABSTRACT
    Parenteral drug delivery systems are the preparations that are given other than oral route. (Para-outside, enteric–intestine). Parenteral drug delivery systems are most preferred drug delivery systems as they meet many benefits over other dosage forms in many cases such as unconsciousness, nausea, in emergency clinical episodes. The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment it is often desirable to maintain systemic drug levels within the therapeutically effective concentration range for as long as treatment calls for. It requires frequent injection, which ultimately leads to patient discomfort. For this reason, drug delivery system which can reduce total number of injection throughout the effective treatment, improve patient compliance as well as pharmacoeconomic. These biodegradable injectable drug delivery system offer attractive opportunities for protein delivery and could possibly extend patent life of protein drugs.Parenteral drug delivery system seeks to optimize therapeutic index by providing immediate drug to the systemic pool in required quantity to treat– cardiac attacks, respiratory attacks. This article explores various prolonged release parenteral drug delivery system and their strategies of preparation, their potential benefits/drawbacks and in-vitro testing methods.

  • ALCOHOL IS SAFE OR DANGEROUS, IS A BIG QUESTION MARK OR WE CAN SAY IT’S A ‘WH’ TYPE QUESTION

    Alcohol means ethyl alcohol are hydroxyl derivatives of aliphatic hydrocarbons. Production of alcohol needs only a few basic ingredients., these are sugar, water, yeast and a warm atmosphere. Alcohol is prepared by the fermentation process by means fermentation of sugar.

  • ROLE OF PURPLE CORN IN TREATMENT OF TYPE 2 DIABETES AND KIDNEY DISEASE: A THERAPEUTIC REVIEW

    About Authors:
    Mr. Satyanand Tyagi
    President, Tyagi Pharmacy Association & Scientific Writer,
    Chattarpur, New Delhi, India.
    Prof. Satyanand Tyagi is a life time member of various pharmacy professional bodies like IPA, APTI and IPGA. He has published various research papers and review articles. His academic works include 50 Publications (42 Review Articles and 08 Research Articles of Pharmaceutical, Medicinal and Clinical Importance, published in standard and reputed National and International Pharmacy journals; Out of 50 publications, 11 are International Publications).
    sntyagi9@yahoo.com,
    +91-9871111375 / 9582025220

    ABSTRACT:
    Diabetic nephropathy is one of the most serious complications related to diabetes, often leading to end-stage kidney disease. Purple corn grown in Peru and Chile is a relative of blue corn, which is readily available in the U.S. The maize is rich in anthocyanins (also known as flavonoids), which are reported to have anti-diabetic properties. Scientists from the Department of Food and Nutrition and Department of Biochemistry at Hallym University in Korea investigated the cellular and molecular activity of purple corn anthocyanins (PCA) to determine whether and how it affects the development of diabetic nephropathy (DN). Their findings suggest that PCA inhibits multiple pathways involved in the development of DN, which may help in developing therapies aimed at type 2 diabetes and kidney disease. The aim of present article is to provide in depth knowledge about Purple Corn, their clinical and biological utility as well as their role in treatments of type 2 diabetes and kidney disease. An attempt is also made to focus on compounds found in purple corn which may aid in developing future treatments for type 2 Diabetes as well as kidney disease.

  • SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG CELECOXIB

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    About Authors:
    Mr. Pranab Prakash Panigrahi1*, Mr. Ajit Kumar Acharya2
    1B.Pharm, ROYAL COLLEGE OF PHARMACY AND HEALTH SCIENCES, BERHAMPUR
    2Asst.Professor, ROYAL COLLEGE OF PHARMACY AND HEALTH SCIENCES, BERHAMPUR

    *pranab.panigrahi@rediffmail.com

    INTRODUCTION
    Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Improvement in the extent and rate of dissolution is highly desirable for such compounds, as this can lead to an increased and more re-producible oral bioavailability and subsequently to clinically relevant dose reduction and more reliable therapy. More than 40% of newly discovered drugs have little or no water solubility presents a serious challenge to the successful development and commercialization of new drugs in the pharmaceutical industry. Now a days, pharmaceutical technology provides many approaches to enhance the dissolution rate of poorly soluble drugs. Physical modifications often aim to increase the surface area, solubility and/or wet ability of the powder particles and are therefore focused on particle size reduction or generation of amorphous states [Hancock, 1997 & Grau, 2000]. Several methods have been employed to improve the solubility of poorly water soluble drugs. A solid dispersion technique has been used by various researchers who have reported encouraging results with different drugs. The first drug whose rate and extent of absorption was significantly enhanced using the solid dispersion technique was sulfathiazole by Sekiguchi and Obi (Sekiguchi, 1961)1.

  • FORMULATION AND INVITRO EVALUATION OF IMMEDIATE RELEASE FOR QUETIAPINE FUMARATE IN TABLET DOSAGE FORM

    About Authors:
    Ashokkumar.m*, M.Senthil kumar, Dinesh, Jenish, Marshel, Hariharan
    Annai veilankanni’s college of pharmacy
    Saidapet, Chennai-600015, Tamilnadu
    *mgashokkumar123@gmail.com

    ABSTRACT
    Atypical antipsychotic Quetiapine was used for the treatment of schizophrenia is a severe illness with substantial effects on individual and social functioning, Quetiapine and its active metabolite N-desalkyl-Quetiapine have affinities to dopaminergic D1-and D2receptors,5-HT2 receptors. To design of immediate release dosage form of quetiapine fumarate that will help in releasing drug with short period of time. The quetiapine fumarate tablets were successfully prepared by direct compression method. The physiochemical evaluation results for the powdered material of all trials pass the official limits in angle of repose, compressibility index and drug content. In the 9 trials, the optimized formulation was F3 trial which releases the quetiapine fumarate  immediately within an hour.

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