Azadirahta indica(Meliaceae)
Of current interest is the tree known as Neem, all parts of the plant continue to receive extensive phytochemical and pharmacological investigation [11]. Aqueous extract of Neem leaves (10-200mg/kg, p.o.) produced Anxiolyitc effect in Elevated Plus Maze and Open Field test in Rats. The extract (500mg/kg/dayX15 days) reduced Cerebral Hypoperfusion induced behavior disturbance of anxiety in rats, assessed in open field test [20, 21].

Citrus sinensis (Rutaceae)
The essential oils from peel (1.0g/kg, p.o.) showed Anxiolytic activity in mice tested in Elevated plus Maze [22].

Euphorbia hirta(Euphorbiaceae)
Lyophilized aqueous extract (12.5 & 25 mg/kg, p.o) produced Anxiolytic effect in Mice employing staircase test & light/ dark situation test. Euphorbane is the active constituents [23].

Ginkgo biloba(Ginkgoaceae)
The leaves of Ginkgo are obtained from the dioeceous tree, the only extant species of an otherwise fossile family of the pre-Ice age flora [11]. The extract (0.063-1g/kg, p.o) administered daily for 7 days in Male ddY mice produced Anxiolytic in Elevated plus Maze [24].

Withania somnifera(Solanaceae)
This plant grows widely in all dry parts and subtropical India. The mail constituents of Ashwagandha are alkaloids and steroidal lactones [17]. Intraperitoneal & oral administration of Glycowithanolides (20 & 50 mg/kg) once daily for 5 days resulted in Anxiolytic effects in Rats employed EPM and Social interaction test. The therapeutic potential of Withania somnifera appears to be related inhibition of both the lipid peroxidation & protein oxidative modification [25].

Zingiber officinale(Zingiberaceae)
Ginger (Zingiber) is the scarped or unscraped rhizome of Zingiber officinale. Ginger contains about 1-2% of Volatile oil and 5-8% of resinous matter, starch and mucilage [17]. Animal treated with butanolic fraction showed anxiolytic activity in Elevated Plus Maze [26].

Panax ginseng(Araliaceae)
Ginseng is the dried root of various species of Panax. Ginseng has generated large interest because of its novel pharmacological actions [17]. Ginseng powder and crude saponin ginseng fraction significantly increased the frequency and duration of open arm entries in male ICR albino mice. Pure ginsenoside; ginsenoside Rb1 (2.5 mg/kg; p.o) increased both frequency and duration of open arm entries [27].

Casimiroa edulis(Rutaceae)
It is found in Mexico. Administration of aqueous extract of leaves (25 mg/kg, p.o) to male Wistar rats increased the exploration of open arms in EPM [28].

Although 28 species of plants have shown Anxiolytic activity in laboratory animals. All plants have been reported to be effective clinically. Most of the species shows aqueous extract of the plant shows anxiolytic activity on different doses as compared to test and the standard drug Diazepam. Diazepam is the most effective and standard drug used in the Anxiolytic activity in pharmacological actions on Animals.

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