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PYRAZOLE AND ITS BIOLOGICAL ACTIVITY


· Sunil Singh K et al., studied the microwave promoted condition and optimized to get a1,5-diaryl-pyrazole and subsequently implemented to the parallel synthesis of different compounds, and they concluded that this was the excellent method for the rapid generation of 1,5-diarylpyrazole using microwave inaqueous medium under normal laboratory condition31.


· El-Saied Aly A et al.,  have shown a new synthetic route for the synthesis of some novel pyrazole derivatives. They prepared some novel pyrazole derivatives by the reaction of 3-aryl-1-phenyl-1H-pyrazolecarbaldehydes as starting material with acylglycine, benzamidine HCl and azidoacetate giving pyrrolopyrazole derivatives32.


Some of the marketed products of pyrazole nucleus are listed below33.

Table 1:Marketedproducts containing Pyrazole moiety



CONCLUSION:
The reviewed Pyrazole is a unique template that is associated with several biological activities. The various substituted pyridine and are having antibacterial, anticonvulsant, analgesic, antimicrobial, anti-inflammatory, ant diabetic, sedative antirheumatic, anticancer, and antitubercular activitiesThis article high lightened research work of many researchers reported in literature for different  pharmacological activities on pyrazole compounds synthesized. The review has presented comprehensive details of pyrazole analogues, potent compounds reported for particular pharmacological activity and the method or technique involved in evaluation process. More investigations must be carried out to evaluate more activities of pyrazole for many diseases.

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