Preparation and Evaluation of Fast Dissolving Tablets for an Selected Drug
About Author: Vipul Kumar Tyagi (B.Pharm)
Shri Gopichand College Of Pharmacy,
Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. A fast dissolving tablet was prepared by using various super disintegrants taken in different concentration (10%, 12%, and 14%) and one control batch is prepared without disintegrants designated as four different groups of formulations(F-1,F-2,F-3 and F-4) . Chemical incompatibility studies confirmed that there is no interaction between drug and excipients used in the formulations. All the batches are prepared by direct compression method. Effect of disintegrants on the disintegration behaviour was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay.Direct compression method involves the incorporation of superdisintegrants in to the formulation. Direct compression does not require water or heat during formulation procedure and it is well suited for moisture and heat sensitive drugs. Fast dissolving tablets have so many advantages over liquid dosage form and conventional tablets. Fast dissolving tablet is suited for tablets which are undergoing first pass effect, and it is increase their bioavailability. A fast-dissolving drug delivery system, in most cases, is a tablet that dissolves or disintrigrants in the oral cavity without the need of water or chewing. Most fast-dissolving delivery system films must include substances to mask the taste of the active ingredient. This masked active ingredient is then swallowed by the patient’s saliva along with the soluble and insoluble excipients. These are also called melt-in-mouth tablets, repimelts, porous tablets, oro-dispersible, quick dissolving or rapid disintegrating tablets.
Reference ID: PHARMATUTOR-ART-1117
An ideal Properties of Fast Dissolving Tablets
· Require no water for oral administration, yet dissolve / disperse/ disintegrate in mouth in a matter of seconds.
· Have a pleasing mouth feel.
· Have an acceptable taste masking property.
· Be harder and less friable Leave minimal or no residue in mouth after administration
· Exhibit low sensitivity to environmental conditions (temperature and humidity).
· Allow the manufacture of tablet using conventional processing and packaging equipments.
Advantages of Fast Dissolving Tablets
Administration to the patients who can not swallow, such as the elderly, stroke victims, bedridden patients, patients affected by renal failure & patients who refuse to swallow such as pediatric, geriatric & psychiatric patients. Rapid drug therapy intervention. Achieve increased bioavailability/rapid absorption through
pregastric absorption of drugs from mouth, pharynx & oesophagus as saliva passes down. Convenient for administration and patient compliant for disabled, bedridden patients and for travelers and busy people, who do not always have access to water. Good mouth feel property helps to change the perception of medication as bitter pill particularly in pediatric patients. The risk of chocking or suffocation during oral administration of conventional formulations due to physical obstruction is avoided, thus providing improved safety. New business opportunity like product differentiation, product promotion, patent extension and life cycle management.
Salient Features of Fast Dissolving Drug Delivery System
· Ease of administration to patients who refuse to swallow a tablet, such as paediatric and geriatric patients and, psychiatric patients.
· Convenience of administration and accurate dosing as compared to liquids.
· No need of water to swallow the dosage from, which is highly convenient feature for patients who are traveling and do not have immediate access to water.
· Good mouth feels properly of MDDS helps to change the basic view of medication as “bitter pill”, particularly for paediatric patients.
· Rapid dissolution of drug and absorption which may produce rapid, onset of action.
· Some drugs are absorbed from the month pharynx and oesophagus as the saliva passes down into the stomach, in such cases bioavailability of drugs is increased.
· Ability to provide advantages of liquid medication in the form of solid preparation.
· Pregastric absorption can result in improved bioavailability and as a result of reduced dosage, improved clinical performance through a reduction of unwanted effects.
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