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Preparation and Evaluation of Fast Dissolving Tablets for an Selected Drug


Patented Technologies For Fast Dissolving Tablets
Zydis Technology

Zydis, the best known of the fast-dissolving/disintegrating tablet preparations was the first marketed new technology tablet. The tablet dissolves in the mouth within seconds after placement on the tongue. A Zydis tablet is produced by lyophilizing or freeze-drying the drug in a matrix usually consisting of gelatin. The product is very lightweight and fragile, and must be dispensed in a special blister pack. Patients should be advised not to push the tablets through the foil film, but instead peel the film back to release the tablet. The Zydis product is made to dissolve on the tongue in 2 to 3 seconds. The Zydis formulation is also self-preserving because the final water concentration in the freeze-dried product is too low to allow for microbial growth.

Durasolv Technology
Durasolv is the patented technology of CIMA labs. The tablets made by this technology consist of a drug, fillers and a lubricant. Tablets are prepared by using conventional tableting equipment and have good rigidity. These can be packed into conventional packaging system like blisters. Durasolv is an appropriate technology for products requiring low amounts of active ingredients.

Orasolv Technology
Orasolv Technology has been developed by CIMA labs. In this system active medicament is taste masked. It also contains effervescent disintegrating agent. Tablets are made by direct compression technique at low compression force in order to minimize oral dissolution time. Conventional blenders and tablet machine is used to produce the tablets. The tablets produced are soft and friable and packaged in specially designed pick and place system.

Flash Dose Technology
Flash dose technology has been patented by Fuisz. Nurofen meltlet, a new form of ibuprofen as melt-in-mouth tablets, prepared using flash dose technology is the first commercial product launched by Biovail Corporation. Flash dose tablets consists of self binding shearform matrix termed as “floss”. Shearform matrices are prepared by flash heat processing.

Wowtab Technology
Wowtab Technology is patented by Yamanouchi Pharmaceutical Co. WOW means “Without Water “. In this process, combination of low mouldability saccharides and high mouldability saccharides is used to obtain a rapidly melting strong tablet. The active ingredient is mixed with a low mouldability saccharide and granulated with a high mouldability saccharide and compressed into tablet.

Flashtab Technology
Prographarm laboratories have patented the Flashtab technology. Tablets prepared by this system consist of an active ingredient in the form of micro crystals. Drug micro granules may be prepared by using the conventional techniques like coacervation, micro encapsulation, and extrusion spheronisation. All the processing utilized conventional tabletting technology.

Promising Drugs to be in corporated In Fast Dissolving Tablets
There are no particular limitations as long as it is a substance which is used as a pharmaceutical active ingredient.

Analgesics and Anti-inflammatory Agents:
Aloxiprin,
Auranofin,
Azapropazone,
Benorylate,
Diflunisal.

Anthelmintics:
Albendazole,
Bephenium Hydroxynaphthoate,
Cambendazole,
Dichlorophen,
Mebendazole,

Anti-Arrhythmic Agents:
Amiodarone,
Disopyramide,
Flecainide Acetate,
Quinidine
Sulphate.

Anti-bacterial Agents:
Benethamine Penicillin,
Cinoxacin,
Ciprofloxacin,
Clarithromycin,
Clofazimine,

Anti-coagulants:
Dicoumarol,
Dipyridamole,
Nicoumalone,
Phenindione.

Anti-Depressants:
Amoxapine,
Ciclazindol,
Maprotiline,
Mianserin,
Nortriptyline,

Anti-Epileptics:
Beclamide,
Carbamazepine,

Clonazepam,
Ethotoin,
Methoin,

Anti-Fungal Agents:
Amphotericin,
Butoconazole Nitrate,
Clotrimazole,
Econazole Nitrate,
Fluconazole,

Anti-Hypertensive Agents:
Amlodipine,
Carvedilol,
Benidipine,
Darodipine,
Dilitazem,

Anti-Malarials:
Amodiaquine,
Chloroquine,
Chlorproguanil,
Halofantrine,
Mefloquine,

Anti-Thyroid Agents:
Carbimazole,
Propylthiouracil.

Anxiolytic, Sedatives, Hypnotics And Neuroleptics:
Alprazolam,
Amyiobarbitone,
Barbitone,
Bentazeparn,
Bromazepam,

Diuretics:
Acetazolarnide,
Amiloride,
Bendrofluazide,
Bumetanide,
Chlorothiazide,

Gastro-Intestinal Agents:
Bisacodyi,
Cimetidine,
Cisapride,
Diphenoxylate,
Domperidone,

Opioid Analgesics:
Codeine,
Dextropropyoxyphene,
Diamorphine,
Dihydrocodeine,
Meptazinol,

Stimulants:
Amphetamine,
dexamphetamine,
dexfenfluramine,
fenfluramine,
mhazindol,
pemoline.

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