You are herePHYTOCHEMICAL INVESTIGATION AND ANTIDIABETIC ACTIVITY STUDIES OF MORINGA OLIEFERA ROOTS

PHYTOCHEMICAL INVESTIGATION AND ANTIDIABETIC ACTIVITY STUDIES OF MORINGA OLIEFERA ROOTS


Table 4: Evaluation of Moringa oliefera root extracts on for the antidiabetic activity.

Sr. No.

Groups

Day 1

Day 7

Day 14

Day 21

1

Normal

91.16±10.36

91.34±7.86

93.33±7.88

90.23±8.74

2

Control

217±12.03

311±14.65

291±7.36

328±4.5

 3

MO Aq.

186.33±8.22

259.66±11.21

233±12.01

222±11.08

4

MO Alc.

220.66±5.02

205.5±6.34

187±12.00

150.5±14.5

5

Standard

234±18.47

209±13.46

167±17.33

89±9.00

Blood Glocose Level
MO root extracts had shown antidiabetic effect on STZ-induced diabetic wistar albino rats. MO root extracts had prevented the loss of body weight. MO aqueous extract  had shown significant (p ≤0.05) decreases in elevated blood glucose level from (259.66±11.21) to (222±11.08) and MO alcoholic extract  had also shown decreases in blood glucose level from (220.66±5.02) to (150.5±14.5) in comparison with Diabetic control group. The results were shown in Table 5.
Diabetic rats exhibited significantly higher glucose level compared to normal rats. Treatment with of MO extracts significantly decreased elevated glucose levels in diabetic rats. The decrease in glucose levels in alcoholic extract of MO shows significant decrease in glucose level compared to aqueous extract exhibited significant(p<0.05) glucose lowering activity. The results were shown in Figure 5.

Table 5: Evaluation of Moringa oliefera root extracts on for the antihyperlipidemic activity.

Sr. No.

Groups

TC

HDL-C

LDL-C

TG

LDL/HDL

TC/HDL

1

Normal

128±9.85

36±2.08

38.00±5.01

81.33±2.9

1.8±0.012

2.08±0.1

2

Control

86±7.57

17.66±0.88

63.00±6.88

137.0±4.95

2.37±0.05

8.59±0.09


 3

MO Aq.

70.33±2.18

18.67±2.90

32.66±3.84

123.2±7.0

2.00±0.03

3.25±0.2

4

MO Alc.

85.00±9.16

24.33±5.03

38.66±1.03

108.8±4.8

2.20±0.06

4.37±0.02

5

Standard

54±1.73

14±0.57

24.66±0.57

115±6.27

1.60±0.065

3.09±0.08

Serum cholesterol
High cholesterol diet rats that are control group exhibited significantly higher cholesterol level in diabetic rats. Treatment with of MO extracts significantly decreased elevated cholesterol levels in hyperlipidemic rats. The decrease in cholesterol levels in aqueous extract (70.33***±2.18) of MO showed significant decrease in cholesterol level compared to alcoholic extract (85.00**±9.16) exhibited significant (p<0.05) cholesterol lowering activity. However, alcoholic extract was also significantly reduced TC when compared with control group (86.0**±7.57). The results were shown in  Table 5 and Figure 6.

Serum HDL-Cholesterol
High cholesterol diet rats that are control group (17.66**±0.88) exhibited significantly lower HDL-C levels as compared to normal control rats (36.0±2.08). Treatment with extracts of MO significantly increased HDL-C levels. The rate of increase in HDL-C level in alcoholic extract (24.33*±5.03) was higher compared to aqueous extract (18.67**±2.90) of MO exhibited significant (p<0.001). The results were shown in  Table 5 and Figure 6.

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