You are hereIMIDAZOLE: SYNTHESIS, PROPERTIES AND BIOLOGICAL ACTIVITY

IMIDAZOLE: SYNTHESIS, PROPERTIES AND BIOLOGICAL ACTIVITY


CONCLUSION:
Vast number of imidazole containing compounds have been synthesized and evaluated for their biological activity.Microwave reactions are extremely attractive to synthetic organic chemists owing to their ability to improve region and/or chemoselectivity and for ecofriendly & lesser reaction times. In case of imidazoles derivatives which are proved to be having great potential for the different pharmacological activities, therefore synthesis of these by using microwave techniques are found to be further advantageous.   

Imidazole moiety have been most frequently studied, many of its analogs are active against various pathologicalconditions, which are discussed in brief in this article. Imidazole is an entity which has interesting physical and chemical properties, in the present article focus lies on analysis of these properties which in turn may be exploited for different pharmacological activities, like compounds having a 3,4,5-trimethoxyphenyl ring linked to either N-1 or C-4 position of the imidazole entity gave an interesting profile of cytotoxicity with specific activity against leukemia cell lines, combination of indole-imidazole compounds formed demonstrated substantial in vitro anti proliferative activities against cancer cell lines, effective substitutions are also made in the entity  which resembles structures of various natural compounds whose anti cancerous activity has already been  examined. Substitutions are discussed in pharmacological actions as anti neoplastic agent.

On the basis of various literature survey imidazole derivatives show various activity against antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic imidazole nucleus. Having structural similarity with histidine imidazole compound can bind with protein molecules with ease compared to the some other heterocyclic moieties. Thus imidazole offers better pharmacodynamic characteristics. Furthermore, some imidazoles drugs, at high concentrations, could exert direct inhibitory effects on membranes, without interference with sterols and sterol esters. Various recent new drugs developments in imidazoles derivatives show better effect and less toxicity.

Thus can say Imidazole is a moiety which had been exploited in the past years for synthesizing various compounds having diverse pharmacological activities, and still it can be further utilized for future prospective against various pathological conditions and other uses.

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