You are hereFORMULATION AND IN VITRO EVALUATION OF METOCLOPRAMIDE HYDROCHLORIDE MICROSPHERES PREPARED BY SOLVENT EVAPORATION METHOD

FORMULATION AND IN VITRO EVALUATION OF METOCLOPRAMIDE HYDROCHLORIDE MICROSPHERES PREPARED BY SOLVENT EVAPORATION METHOD


RESULTS AND DISCUSSION
The present study was an attempt to develop and characterize microspheres of metoclopramide hydrochloride. Emulsification solvent evaporation method was used for preparation of microspheres.

Scanning electron microscopy (SEM):
Morphology of microspheres was examined by scanning electron microscopy. The view of the microspheres showed hollow structure with a smooth surface morphology (fig. 1)exhibited range of sizes within each batch (shown in table 3). The outer surface of microspheres was smooth and dense.


Fig. 1: Scanning electron microphotographs of metoclopramide hydrochloride microsphere (F-2).

Infrared spectroscopy:
The FT?IR spectra study showed no change in the finger print of pure drug spectra, thus confirming absence of drug and polymer interaction.


FTIR spectrum of metoclopramidehydrochloride

Fig. 2: Image showing drug polymer interaction study by FTIR

Particle size analysis:
Particle size analysis of different formulations was done by optical microscopy. The average particle size was found to be in the range of 45.6 to 52.2 μm. The mean particle size was significantly increases with increasing polymer concentration this may be due to high viscosity of polymer solution. Since high viscosity of polymer solution requires high shearing energy for breaking of droplets of the emulsion.

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